3-[3-[[8-[4-[2-[3-[3-[3-[3-(2-Aminoethoxy)propoxy]propoxy]propoxy]propoxy]ethoxy]phenyl]-2-methoxy-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-2-methoxy-8-(4-methoxyphenyl)-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 3-[3-[[8-[4-[2-[3-[3-[3-[3-(2-Aminoethoxy)propoxy]propoxy]propoxy]propoxy]ethoxy]phenyl]-2-methoxy-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-2-methoxy-8-(4-methoxyphenyl)-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
• 英文别名: 3-[3-[[8-[4-[2-[3-[3-[3-[3-(2-aminoethoxy)propoxy]propoxy]propoxy]propoxy]ethoxy]phenyl]-2-methoxy-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]propoxy]-2-methoxy-8-(4-methoxyphenyl)-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
• 化学式: C₅₈H₇₁N₅O₁₃
• 分子量: 1046.2
• InChiKey: CEEBCZYWGJAQAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  76
• 可旋转键数：
  33
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  193
• 氢给体数：
  1
• 氢受体数：
  16

文献信息

• ANTIBODY-ACTIVE AGENT CONJUGATES AND METHODS OF USE
  申请人：LegoChem Biosciences, Inc.

  公开号：US20140161829A1

  公开（公告）日：2014-06-12

  The invention provides protein-active agent conjugates having an amino acid motif that can be recognized by an isoprenoid transferase. The invention also provides compositions containing the conjugates. The invention further provides methods for using the conjugates to deliver the active agent to a target cell, as well as methods for using the conjugates to treat a subject in need thereof (e.g., a subject in need of the active agent).