ethyl (2S)-6-anilino-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxohexanoate | 1237582-50-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl (2S)-6-anilino-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxohexanoate
• CAS: 1237582-50-1
• 化学式: C₁₉H₂₈N₂O₅
• 分子量: 364.442
• InChiKey: AQCYDWQGKDOQTJ-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  93.7
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  苯胺 、 (S)-ethyl 2-(((tert-butoxy)carbonyl)amino)-6-diazo-5-oxohexanoate 在 Ru(meso-tetraphenylporphyrinato)(CO)2 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以71%的产率得到ethyl (2S)-6-anilino-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxohexanoate
  参考文献：
  名称：

  Chemical reactivity of 6-diazo-5-oxo-l-norleucine (DON) catalyzed by metalloporphyrins (Fe,Ru)

  摘要：

  The transfer of the metallocarbene derived from N- and O-protected 6-diazo-5-oxo-L-norleucine (DON) catalyzed by metalloporphyrins undergoes dimerization, cyclopropanation. N-H and S-H insertion reactions, respectively. An efficient and direct synthesis of 5-oxo-L-pipecolic acid from DON is described from unprotected 6-diazo-5-oxo-L-norleucine. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2010.04.080

文献信息

• Chemical reactivity of 6-diazo-5-oxo-l-norleucine (DON) catalyzed by metalloporphyrins (Fe,Ru)
  作者：Paul Le Maux、Irène Nicolas、Soizic Chevance、Gérard Simonneaux

  DOI：10.1016/j.tet.2010.04.080

  日期：2010.6

  The transfer of the metallocarbene derived from N- and O-protected 6-diazo-5-oxo-L-norleucine (DON) catalyzed by metalloporphyrins undergoes dimerization, cyclopropanation. N-H and S-H insertion reactions, respectively. An efficient and direct synthesis of 5-oxo-L-pipecolic acid from DON is described from unprotected 6-diazo-5-oxo-L-norleucine. (C) 2010 Elsevier Ltd. All rights reserved.