4-Methansulfonamido-pyridin | 109233-77-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-Methansulfonamido-pyridin
• 英文别名: N-pyridin-4-yl-methanesulfonamide；Methanesulfonamide, N-4-pyridinyl-；N-pyridin-4-ylmethanesulfonamide
• CAS: 109233-77-4
• 化学式: C₆H₈N₂O₂S
• mdl: MFCD01213913
• 分子量: 172.208
• InChiKey: HBBSAGHMADHTBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-氨基吡啶 、 三乙胺 、 甲基磺酰氯 在 ice 、 crude product 、 乙腈 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 21.0h， 生成 4-Methansulfonamido-pyridin
  参考文献：
  名称：

  Catalysts for selective isocyanate dimerization

  摘要：

  一种使用磺酰胺阴离子作为异氰酸酯二聚化催化剂的方法，以及使用这种催化剂制备寡聚异氰酸酯的过程。

  公开号：

  US07317112B2

文献信息

• [EN] PYRIMIDINYL-PYRIDYLOXY-NAPHTHYL COMPOUNDS AND METHODS OF TREATING IRE1-RELATED DISEASES AND DISORDERS<br/>[FR] COMPOSÉS PYRIMIDINYL-PYRIDYLOXY-NAPHTYLE ET PROCÉDÉS DE TRAITEMENT DE MALADIES ET DE TROUBLES LIÉS À IRE1
  申请人：GENENTECH INC

  公开号：WO2018166528A1

  公开（公告）日：2018-09-20

  Described herein are pyrimidinyl-pyridyloxy-naphthyl compounds with inositol requiring enzyme 1 (IRE1) modulation activity or function having the Formula (I) or (I') structure : or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula (I) or (I') compounds, as well as methods of using such IRE1 modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon estrogen receptors.

  本文描述了具有肌醇需要酶1（IRE1）调节活性或功能的嘧啶基-吡啶氧基-萘基化合物，其具有公式（I）或（I'）结构：或其立体异构体，互变异构体或药学上可接受的盐，并具有所述的取代基和结构特征。还描述了包括公式（I）或（I'）化合物的制药组合物和药物，以及使用这种IRE1调节剂的方法，单独或与其他治疗剂联合治疗介导或依赖于雌激素受体的疾病或病况。
• HEPATITIS B ANTIVIRAL AGENTS
  申请人：ENANTA PHARMACEUTICALS, INC.

  公开号：US20170355701A1

  公开（公告）日：2017-12-14

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, thereof: which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. The invention also relates to methods of treating an HBV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了式（I）的化合物或其药学上可接受的盐：这些化合物抑制由乙型肝炎病毒（HBV）编码的蛋白质或干扰乙型肝炎病毒的生命周期功能，并且还可用作抗病毒剂。本发明还涉及包括上述化合物的药物组合物，用于给患有HBV感染的受试者使用。该发明还涉及通过给予包含本发明化合物的药物组合物来治疗受试者的HBV感染的方法。
• [EN] SUBSTITUTED PYRIDIN-4-YL-METHYL SULFONAMIDESAS FUNGICIDES<br/>[FR] PYRIDIN-4-YL-MÉTHYL SULFONAMIDES SUBSTITUÉS EN TANT QUE FONGICIDES
  申请人：BASF SE

  公开号：WO2009144159A1

  公开（公告）日：2009-12-03

  The present invention relates to pyridin-4-ylmethyl sulfonamides of formula I wherein Het, Ra, Rc, Rf, m, n, p, R, A and Y are as defined in the claims, to the N-oxides, and salts thereof and their use for combating harmful fungi, and also to compositions and seed comprising at least one such compound. The invention also relates to a process and intermediates for preparing these compounds.

  本发明涉及公式I中的吡啶-4-基甲基磺酰胺，其中Het、Ra、Rc、Rf、m、n、p、R、A和Y如权利要求所定义，以及其N-氧化物和盐，用于对抗有害真菌，还涉及至少包含一种这样的化合物的组合物和种子。本发明还涉及制备这些化合物的过程和中间体。
• New catalysts for selective isocyanate dimerization
  申请人：Kocher Jurgen

  公开号：US20050033006A1

  公开（公告）日：2005-02-10

  A method of dimerizing isocyanates using sulphonamide anions as a dimerization catalyst for the isocyanates and also to a process for preparing oligomeric isocyanates using such catalysts.

  一种使用磺酰胺阴离子作为异氰酸酯二聚化催化剂的方法，以及使用此类催化剂制备寡聚异氰酸酯的过程。
• DISPERSION OF WATER-INSOLUBLE COLORANT, METHOD OF PRODUCING SUBSTANCE CONTAINING WATER-INSOLUBLE COLORANT, FINE PARTICLES OF WATER-INSOLUBLE COLORANT, DISPERSING AGENT FOR WATER-INSOLUBLE COLORANT, AND RECORDING LIQUID, INK SET, PRINTED ARTICLE, METHOD OF FORMING IMAGE AND IMAGE FORMING APPARATUS USING THE SAME
  申请人：SANO Satoshi

  公开号：US20090246481A1

  公开（公告）日：2009-10-01

  A dispersion of a water-insoluble colorant containing: a medium containing water; fine particles of the water-insoluble colorant; and a polymer compound or a surfactant that includes at least one kind of electron-withdrawing group or group of atoms represented by any one of formulae (I) to (IV) as its hydrophilic part: wherein at least one of X 1 and X 2 represents an electron-withdrawing linking group on the condition that when at least one of X 1 and X 2 is not the linking group, the at least one of X 1 and X 2 represents an electron-withdrawing substituent; R 1 represents a hydrogen atom or a substituent; and M represents a hydrogen atom or a metal atom.

  一种水不溶性着色剂的分散体，包括：含水介质；水不溶性着色剂的细小颗粒；以及聚合物化合物或表面活性剂，其包含至少一种电子吸引基团或由式（I）至（IV）中的任何一种原子团表示的原子团作为其亲水部分：其中X1和X2中至少一个表示电子吸引连接基团，条件是当X1和X2中至少一个不是连接基团时，X1和X2中的至少一个表示电子吸引取代基；R1表示氢原子或取代基；M表示氢原子或金属原子。