oxalic acid;(4S,9S)-spiro[4.4]nonane-4,9-diamine

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: oxalic acid;(4S,9S)-spiro[4.4]nonane-4,9-diamine
• 化学式: C11H20N2O4
• 分子量: 244.29
• InChiKey: VYKOORQSIPZXGF-IWKQBAGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.15
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  127
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• TETRAVALENT PLATINUM COMPLEX AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
  申请人：Unitech Co., Ltd

  公开号：EP2743252A1

  公开（公告）日：2014-06-18

  New platinum(IV) complexes which has a strong antitumor activity and has a feature that a side effect is relatively reduced is provided. The new complex is platinum(IV) complexes with cis,cis-spiro[4,4]nonane-1,6-diamine ligand and is platinum(IV) complexes with optically active cis,cis-spiro[4,4]nonane-1,6-diamine ligand. Especially, the new complex is dichloromalonato((1S,5S,6S)-spiro[4.4]nonane-1,6-diamine)platinum(IV).

  新的铂(IV)配合物具有很强的抗肿瘤活性，而且副作用相对较小。新配合物是具有顺式、顺式螺[4,4]壬烷-1,6-二胺配体的铂(IV)配合物，是具有光学活性的顺式、顺式螺[4,4]壬烷-1,6-二胺配体的铂(IV)配合物。特别是，新配合物是二氯丙二酸（(1S,5S,6S)-螺[4.4]壬烷-1,6-二胺）铂（IV）。
• PLATINUM(IV) COMPLEXES AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
  申请人：Arai Hisae

  公开号：US20140221475A1

  公开（公告）日：2014-08-07

  New platinum(IV) complexes which has a strong antitumor activity and has a feature that a side effect is relatively reduced is provided. The new complex is platinum(IV) complexes with cis,cis-spiro[4,4]nonane-1,6-diamine ligand and is platinum(IV) complexes with optically active cis,cis-spiro[4,4]nonane-1,6-diamine ligand. Especially, the new complex is dichloromalonato((1S,5S,6S)-spiro[4.4]nonane-1,6-diamine)platinum(IV).