3-(phenylamino)-4-p-tolyl-1H-pyrrole-2,5-dione | 264213-22-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(phenylamino)-4-p-tolyl-1H-pyrrole-2,5-dione
• 英文别名: 3-Anilino-4-(4-methylphenyl)pyrrole-2,5-dione
• CAS: 264213-22-1
• 化学式: C₁₇H₁₄N₂O₂
• 分子量: 278.31
• InChiKey: OVMQROSFJMJSIY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(4-methoxybenzyl)-3-(phenylamino)-4-p-tolyl-1H-pyrrole-2,5-dione 在 aluminum (III) chloride 、 苯甲醚 作用下， 以73%的产率得到3-(phenylamino)-4-p-tolyl-1H-pyrrole-2,5-dione
  参考文献：
  名称：

  Development of Methods for the Synthesis of Libraries of Substituted Maleimides and α,β-Unsaturated-γ-butyrolactams

  摘要：

  Synthetic methods for the preparation of maleimide and alpha,beta-unsaturated-gamma-butyrolactam compound collections are described. These routes take advantage of Pd cross-coupling and conjugate addition/elimination reactions to permit the facile production of bisaryl-maleimides, anilinoaryl-maleimides, and bisanilino-maleimides while allowing control over the synthesis of symmetrical or nonsymmetrical derivatives. Similarly, the chemistry developed allows for the generation of bisaryl substituted alpha,beta-unsaturated-gamma-butyrolactams. The scope and limitations of the approaches are presented.

  DOI：

  10.1021/jo1025805

文献信息

• FUNGIZIDE MITTEL ENTHALTEND ALS WIRKSTOFFE PYRROLIDONE
  申请人：BASF AKTIENGESELLSCHAFT

  公开号：EP1133229A1

  公开（公告）日：2001-09-19
• [DE] FUNGIZIDE MITTEL ENTHALTEND ALS WIRKSTOFFE PYRROLIDONE<br/>[EN] FUNGICIDES CONTAINING PYRROLIDONES AS THEIR ACTIVE AGENTS<br/>[FR] PRODUITS FONGICIDES CONTENANT COMME PRINCIPES ACTIFS DES PYRROLIDONES
  申请人：BASF AG

  公开号：WO2000030445A1

  公开（公告）日：2000-06-02

  Gegenstand der vorliegenden Erfindung sind fungizide Mittel enthaltend als Wirkstoffe Verbindungen der Formel (I), wobei die Reste folgende Bedeutungen haben: R1 Wasserstoff, C¿1?-C6-Alkyl, C1-C6-Alkylcarbonyl, Formyl oder C1-C6-Halogenalkylcarbonyl; R?2¿ Wasserstoff, C¿1?-C6-Alkyl oder C1-C6-Halogenalkyl; R?3-R12¿ Wasserstoff, Halogen, C¿1?-C8-Cycloalkyl, C1-C6-Alkyl, C1-C6-Halogenalkyl, C1-C6-Alkoxy, C1-C6-Halogenalkoxy, C1-C6-Alkylsulfonyl, C1-C6-Halogenalkylsulfonyl, Formyl, Cyano, C1-C6-Alkylthio oder Phenyl, welches ggf. durch Halogenatome, C1-C6-Alkyl- oder C1-C6-Halogenalkyl-Gruppen substituiert sein kann, sowie deren landwirtschaftlich einsetzbaren Salze. Ferner betrifft die Erfindung Verfahren zur Bekämpfung von Schadpilzen bei Pflanzen unter Verwendung dieser fungiziden Mittel.
• Development of Methods for the Synthesis of Libraries of Substituted Maleimides and α,β-Unsaturated-γ-butyrolactams
  作者：Emelia Awuah、Alfredo Capretta

  DOI：10.1021/jo1025805

  日期：2011.5.6

  Synthetic methods for the preparation of maleimide and alpha,beta-unsaturated-gamma-butyrolactam compound collections are described. These routes take advantage of Pd cross-coupling and conjugate addition/elimination reactions to permit the facile production of bisaryl-maleimides, anilinoaryl-maleimides, and bisanilino-maleimides while allowing control over the synthesis of symmetrical or nonsymmetrical derivatives. Similarly, the chemistry developed allows for the generation of bisaryl substituted alpha,beta-unsaturated-gamma-butyrolactams. The scope and limitations of the approaches are presented.