(8S)-1,3,8-trimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8-dihydro-1H-pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]thiazine-2,4(3H,10H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: (8S)-1,3,8-trimethyl-10-(4-methylthiazol-2-yl)-5-phenyl-7,8-dihydro-1H-pyrimido[4',5':3,4]pyrrolo[2,1-c][1,4]thiazine-2,4(3H,10H)-dione
• 英文别名: (11S)-3,5,11-trimethyl-13-(4-methyl-1,3-thiazol-2-yl)-8-phenyl-12-thia-3,5,9-triazatricyclo[7.4.0.02,7]trideca-1,7-diene-4,6-dione
• 化学式: C₂₂H₂₂N₄O₂S₂
• 分子量: 438.574
• InChiKey: SCWJMTRWNKOOKE-YTJLLHSVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  112
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• TRICYCLIC COMPOUNDS
  申请人：AHMED Mahbub

  公开号：US20140171417A1

  公开（公告）日：2014-06-19

  The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了一种式I的化合物或其药学上可接受的盐；以及其治疗用途。本发明还提供了一种药理活性剂的组合和一种药物组合物。
• TRICYCLIC COMPOUNDS FOR INHIBITING THE CFTR CHANNEL
  申请人：AHMED Mahbub

  公开号：US20150336986A1

  公开（公告）日：2015-11-26

  The present invention provides a compound of formula I or a pharmaceutically acceptable salt thereof; and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

  本发明提供了I式化合物或其药学上可接受的盐；以及其治疗用途。本发明还提供了一种药理活性剂的组合和制药组合物。
• PROCESS FOR PRODUCING RUBBER COMPOSITION
  申请人：Katou Seiichi

  公开号：US20140171580A1

  公开（公告）日：2014-06-19

  Process for producing a rubber composition comprising a rubber component (A) comprising at least one selected from natural rubbers and synthetic diene rubbers, a filler containing an inorganic filler (B), a silane coupling agent (C), and at least two kinds of chemical agents (D) and (E) selected from guanidines, sulfenamides, thiazoles, thiurams, dithiocarbamates, thioureas, and xanthates, wherein the rubber composition is kneaded in a plurality of stages wherein, in the first stage (X) of kneading, the rubber component (A), all or a portion of the inorganic filler (B), all or a portion of the silane coupling agent (C), and at least two kinds of the chemical agents (D) and (E) are added and kneaded.
• US9359381B2
  申请人：——

  公开号：US9359381B2

  公开（公告）日：2016-06-07
• US9822246B2
  申请人：——

  公开号：US9822246B2

  公开（公告）日：2017-11-21