3-(4-isothiocyanatophenyl)-2H-isoindole-1-carbonitrile

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 3-(4-isothiocyanatophenyl)-2H-isoindole-1-carbonitrile
• 化学式: C₁₆H₉N₃S
• 分子量: 275.3
• InChiKey: QIFIDHYBIGSBLK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• SYSTEM AND METHOD FOR DETERMINING AMINO ACID SEQUENCE OF POLYPEPTIDE
  申请人：CHUNG YUAN CHRISTIAN UNIVERSITY

  公开号：US20140170759A1

  公开（公告）日：2014-06-19

  This invention discloses systems and methods for determining the sequence of amino acids in a short peptide chain that constructs a protein. The protein is firstly hydrolyzed to various short peptides and amino acid enantiomers. Then, the systems and method are used to separate the short peptides and the amino acid enantiomers, identify qualitatively each of the amino acid enantiomers, and obtain the molecular mass signal for each of the peptides. After that, the identified amino acid enantiomers are used to construct any possible short peptides in an order from the smallest molecular weight dipeptide to higher molecular weight short peptides, and the correct short peptides is confirmed by matching the molecular weight obtained from the mass spectrometry measurement, then, the short peptides are combined to give a large peptide. The process is continued until the whole amino acid sequence of the peptide chain of protein can be determined.
• US9133512B2
  申请人：——

  公开号：US9133512B2

  公开（公告）日：2015-09-15