5-(2,3-Dioxopyrrolidin-1-yl)tetradecanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-(2,3-Dioxopyrrolidin-1-yl)tetradecanoic acid
• 英文别名: 5-(2,3-dioxopyrrolidin-1-yl)tetradecanoic acid
• 化学式: C₁₈H₃₁NO₄
• 分子量: 325.4
• InChiKey: AOPVKWZCLRDEHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  74.7
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• INSULIN DERIVATIVES FOR DIABETES TREATMENT
  申请人：MASSACHUSETTS INSTITUTE OF TECHNOLOGY

  公开号：US20150320837A1

  公开（公告）日：2015-11-12

  Compounds, compositions, and methods for “smart” delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.

  本文提供了一种“智能”递送治疗、预防或诊断药物的化合物、组合物和方法，例如通过葡萄糖感应胰岛素衍生物的葡萄糖介导递送胰岛素。胰岛素衍生物在体内结合血清白蛋白或聚集。在高血糖情况下，葡萄糖与葡萄糖感应元素的络合改变胰岛素衍生物的性质，导致其有效解离以释放胰岛素。这些化合物、组合物和方法提供了一种递送策略，用于自我调节和长期的糖尿病管理。
• US9867869B2
  申请人：——

  公开号：US9867869B2

  公开（公告）日：2018-01-16
• [EN] INSULIN DERIVATIVES FOR DIABETES TREATMENT<br/>[FR] DÉRIVÉS D'INSULINE POUR LE TRAITEMENT DU DIABÈTE
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2014093696A2

  公开（公告）日：2014-06-19

  Compounds, compositions, and methods for "smart" delivery of a therapeutic, prophylactic or diagnostic agent, such as glucose-mediated delivery of insulin through glucose-sensing insulin derivatives, are provided. The insulin derivatives bind serum albumin or agglomerate in vivo. The insulin derivatives effectively dissociate to release insulin in a hyperglycemic condition, where the complexation of glucose to a glucose-sensing element alters properties of the insulin derivative leading to the dissociation. The compounds, compositions, and methods provide a delivery strategy for both self-regulated and long-term diabetes management.