5-甲基-3苯基-4-(1H-吡唑-5-基)异噁唑 | 265125-69-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-甲基-3苯基-4-(1H-吡唑-5-基)异噁唑
• 英文名称: 5-methyl-3-phenyl-4-(1H-pyrazol-5-yl)isoxazole
• 英文别名: 5-methyl-3-phenyl-4-(1H-pyrazol-5-yl)-1,2-oxazole
• CAS: 265125-69-7
• 化学式: C₁₃H₁₁N₃O
• 分子量: 225.25
• InChiKey: SLEUFOXJFRMHSK-UHFFFAOYSA-N

物化性质

• 沸点：
  398.8±30.0 °C(Predicted)
• 密度：
  1.225±0.06 g/cm3(Predicted)
• 溶解度：
  21 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  54.7
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders
  申请人：Severance L. Daniel

  公开号：US20060252807A1

  公开（公告）日：2006-11-09

  The present invention relates to compounds and methods useful as inhibitors of p38 kinase for the treatment or prevention and treatment of diseases such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neurodegenerative diseases, and viral diseases.

  本发明涉及化合物和方法，用于作为p38激酶抑制剂的治疗或预防和治疗炎症性疾病、自身免疫性疾病、破坏性骨疾病、增殖性疾病、血管生成性疾病、传染病、神经退行性疾病和病毒性疾病的药物。
• ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS
  申请人：Kalypsys, Inc.

  公开号：EP1871770A1

  公开（公告）日：2008-01-02
• MICROVESICLE AND STEM CELL COMPOSITIONS FOR THERAPEUTIC APPLICATIONS
  申请人：Ashraf Muhammad

  公开号：US20180273906A1

  公开（公告）日：2018-09-27

  Provided herein are stem cell and exosome compositions having therapeutic utility to treat a variety of diseases and disorders, e.g., cardiovascular disease, Duchenne muscular dystrophy, and fibrotic disease.
• CPC EXOSOMES MIRNA373 COMBINATION THERAPIES
  申请人：IPS Heart

  公开号：US20210054344A1

  公开（公告）日：2021-02-25

  Steam cell and exosome compositions via combination therapy, related gene therapy and pluripotent stem cell derived muscle regeneration as having therapeutic utility to treat a variety of diseases and disorders, e.g., cardiovascular disease, Duchenne muscular dystrophy, and fibrotic disease.
• [EN] ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS<br/>[FR] INHIBITEURS ORTHO-TERPHENYLE DE KINASE P38 ET PROCEDES DE TRAITEMENT DES TROUBLES INFLAMMATOIRES
  申请人：KALYPSYS INC

  公开号：WO2006116355A1

  公开（公告）日：2006-11-02

  [EN] The present invention relates to compounds and methods useful as inhibitors of p38 kinase for the treatment or prevention and treatment of diseases such as inflammatory diseases, autoimmune diseases, destructive bone disorders, proliferative disorders, angiogenic disorders, infectious diseases, neurodegenerative diseases, and viral diseases.
  [FR] La présente invention se rapporte à des composés et à des procédés utiles comme inhibiteurs de la kinase p38 pour le traitement ou la prévention et le traitement de maladies telles que les maladies inflammatoires, les maladies auto-immunes, les troubles destructeurs de l'os, les troubles proliférateurs, les troubles angiogéniques, les maladies infectieuses, les maladies neurodégénératives et les maladies virales.