propan-2-yl (2S)-2-(4-propan-2-yloxybutylcarbamoyl)pyrrolidine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: propan-2-yl (2S)-2-(4-propan-2-yloxybutylcarbamoyl)pyrrolidine-1-carboxylate
• 化学式: C₁₆H₃₀N₂O₄
• 分子量: 314.42
• InChiKey: QSDZTFPNGIALOI-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Single-Stranded Nucleic Acid Molecule Having Nitrogen-Containing Alicyclic Skeleton
  申请人：BONAC CORPORATION

  公开号：US20140171633A1

  公开（公告）日：2014-06-19

  Provided is a novel nucleic acid molecule that can be produced easily and efficiently and can inhibit the expression of a gene. The nucleic acid molecule is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes: a region (X); a linker region (Lx); and a region (Xc). The linker region (Lx) is linked between the regions (Xc) and (Xc). The region (Xc) is complementary to the region (X). At least one of the regions (X) and (Xc) includes the expression inhibitory sequence. The linker region (Lx) has a non-nucleotide structure including at least one of a pyrrolidine skeleton and a piperidine skeleton. According to this single-stranded nucleic acid molecule, it is possible to inhibit the expression of the target gene.

  提供一种新型核酸分子，可以轻松高效地制备，并且可以抑制基因表达。该核酸分子是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子包括：区域（X）；连接区域（Lx）；和区域（Xc）。连接区域（Lx）连接在区域（Xc）和（Xc）之间。区域（Xc）与区域（X）互补。区域（X）和（Xc）中至少有一个包含表达抑制序列。连接区域（Lx）具有非核苷酸结构，包括至少一个吡咯烷骨架和哌啶骨架。根据这种单链核酸分子，可以抑制目标基因的表达。
• Single-Stranded Nucleic Acid Molecule for Controlling Gene Expression
  申请人：BONAC CORPORATION

  公开号：US20150011605A1

  公开（公告）日：2015-01-08

  Provided is a novel nucleic acid molecule that is a single-stranded nucleic acid molecule including an expression inhibitory sequence that inhibits expression of a target gene. The single-stranded nucleic acid molecule includes, in sequence from the 5′ side to the 3′ side: a 5′ side region (Xc); an inner region (Z); and a 3′ side region (Yc). The inner region (Z) is composed of an inner 5′ side region (X) and an inner 3′ side region (Y) that are linked to each other. The 5′ side region (Xc) is complementary to the inner 5′ side region (X). The 3′ side region (Yc) is complementary to the inner 3′ side region (Y). At least one of the inner region (Z), the 5′ side region (Xc), and the 3′ side region (Yc) includes the expression inhibitory sequence.

  提供的是一种新型核酸分子，它是一种单链核酸分子，包括一个抑制目标基因表达的表达抑制序列。该单链核酸分子从5'端到3'端的序列包括：一个5'端区域（Xc）；一个内部区域（Z）；以及一个3'端区域（Yc）。内部区域（Z）由内部5'端区域（X）和内部3'端区域（Y）组成，它们彼此连接。5'端区域（Xc）与内部5'端区域（X）互补。3'端区域（Yc）与内部3'端区域（Y）互补。内部区域（Z）、5'端区域（Xc）和3'端区域（Yc）中至少有一个包含表达抑制序列。
• Drug for Disease Caused by Expression of Periostin Except Eye Disease, and Use Thereof
  申请人：AQUA THERAPEUTICS CO., LTD.

  公开号：US20160304866A1

  公开（公告）日：2016-10-20

  The present invention is intended to provide a novel molecule that inhibits the expression of the periostin gene that is effective in treatment of diseases caused by the expression of periostin except for eye diseases. A drug for a disease caused by the expression of periostin except for an eye disease includes, as an expression inhibitory sequence for the periostin gene, a nucleic acid molecule including a nucleotide that has a base sequence represented by any one of SEQ ID NOs: 1 to 19. The drug for disease according to the present invention can inhibit the expression of the periostin gene. Thus, it can be used for treatment of diseases (except for eye diseases) caused by the expression of the periostin gene, specifically skin diseases, respiratory diseases, gastrointestinal diseases, and the like.
• SINGLE-STRANDED NUCLEIC ACID MOLECULE HAVING DELIVERY FUNCTION AND GENE EXPRESSION REGULATING ABILITY
  申请人：BONAC CORPORATION

  公开号：US20180119151A1

  公开（公告）日：2018-05-03

  The present invention provides a single-stranded nucleic acid molecule having a delivery function and capable of inhibiting expression of a target gene. The single-stranded nucleic acid molecule of the present invention is a single-stranded nucleic acid molecule composed of a region (Xc), a linker region (Lx) and a region (X), wherein said region (Xc) is complementary to said region (X), at least one of said region (X) and said region (Xc) contains an expression inhibitory sequence that inhibits expression of the target gene, and a bio-related substance having a delivery function is bonded to at least one selected from the group consisting of the 5′-terminus, the 3′-terminus, and said linker region (Lx).
• US9200278B2
  申请人：——

  公开号：US9200278B2

  公开（公告）日：2015-12-01