methyl 2-[(1R,9R,10S)-17-(cyclopropylmethyl)-4-methoxy-12,17-diazatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-[(1R,9R,10S)-17-(cyclopropylmethyl)-4-methoxy-12,17-diazatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-12-yl]acetate
• 化学式: C₂₃H₃₂N₂O₃
• 分子量: 384.5
• InChiKey: FXEABPXFVJBWJT-XJUOHMSHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• NITROGEN CONTAINING MORPHINAN DERIVATIVES AND THE USE THEREOF
  申请人：Purdue Pharma LP

  公开号：EP2931725B1

  公开（公告）日：2017-02-15
• Nitrogen Containing Morphinan Derivatives and the Use Thereof
  申请人：Purdue Pharma L.P.

  公开号：US20140171461A1

  公开（公告）日：2014-06-19

  The application is directed to compounds of Formula I-A and pharmaceutically acceptable salts and solvates thereof, wherein R 1a -R 3a , R 4 , Y, and Z are defined as set forth in the specification. The invention is also directed to use of compounds of Formula I-A to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.
• US8937084B2
  申请人：——

  公开号：US8937084B2

  公开（公告）日：2015-01-20
• [EN] NITROGEN CONTAINING MORPHINAN DERIVATIVES AND THE USE THEREOF<br/>[FR] DÉRIVÉS DE MORPHINANE CONTENANT DE L'AZOTE ET LEUR UTILISATION
  申请人：PURDUE PHARMA LP

  公开号：WO2014091298A2

  公开（公告）日：2014-06-19

  The application is directed to compounds of Formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein R1-R4, Y, and Z are defined as set forth in the specification. The invention is also directed to use of compounds of Formula (I) to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.