4-(3,4-Dimethyl-1-azacyclooct-5-yn-1-yl)pent-4-enoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(3,4-Dimethyl-1-azacyclooct-5-yn-1-yl)pent-4-enoic acid
• 英文别名: 4-(3,4-dimethyl-1-azacyclooct-5-yn-1-yl)pent-4-enoic acid
• 化学式: C₁₄H₂₁NO₂
• 分子量: 235.32
• InChiKey: TXAKKWLGBBCUDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compositions and Methods for Modification of Biomolecules
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20160243135A1

  公开（公告）日：2016-08-25

  The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).

  本发明提供了经过改性的环烷炔化合物；以及利用这些化合物修饰生物分子的方法。本发明特征在于可以在生理条件下进行的环加成反应。一般而言，本发明涉及将改性的环烷炔与目标生物分子上的偶氮基团反应，生成共价修饰的生物分子。该反应的选择性和其与水相环境的兼容性使其能够应用于体内（例如，细胞表面或细胞内）和体外（例如，合成肽和其他聚合物，生产改性的（例如，标记的）氨基酸）。
• D-Amino Acid Derivative-Modified Peptidoglycan and Methods of Use Thereof
  申请人：The Regents of the University of California

  公开号：US20140170183A1

  公开（公告）日：2014-06-19

  The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.
• D-AMINO ACID DERIVATIVE-MODIFIED PEPTIDOGLYCAN AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：US20170021013A1

  公开（公告）日：2017-01-26

  The present disclosure provides modified bacteria and modified peptidoglycan comprising modified D-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified D-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via a linker.
• US9260371B2
  申请人：——

  公开号：US9260371B2

  公开（公告）日：2016-02-16
• US9303068B2
  申请人：——

  公开号：US9303068B2

  公开（公告）日：2016-04-05