(3S,4R)-3-hydroxy-N',N',4-trimethylhexanediamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (3S,4R)-3-hydroxy-N',N',4-trimethylhexanediamide
• 化学式: C₉H₁₈N₂O₃
• 分子量: 202.25
• InChiKey: STYVWKYOZUWXEK-RQJHMYQMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  83.6
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• CYCLIC DEPSIPEPTIDE COMPOUNDS AND THEIR USES
  申请人：Cypralis Limited

  公开号：US20150259386A1

  公开（公告）日：2015-09-17

  The present invention relates to novel cycloundecadepsipeptide compounds and their analogues which bind and inhibit cyclophilins, have reduced immunosuppressive activity and improved physicochemical properties including water solubility. The present invention further relates to pharmaceutical compositions containing said depsipeptide compounds and their analogues for use in the treatment or prevention of diseases and pathologies which may be ameliorated by the inhibition of cyclophilin activity.

  本发明涉及一种新型环十一肽类化合物及其类似物，其能够结合并抑制环孢菌素，具有降低的免疫抑制活性和改善的物理化学性质，包括水溶性。本发明还涉及包含所述depsipeptide化合物及其类似物的药物组合物，用于治疗或预防可能通过抑制环孢菌素活性而改善的疾病和病理状态。
• NOVEL PHARMACEUTICAL FORMULATIONS AND THEIR USE IN THE TREATMENT OF PERIODONTAL DISEASE
  申请人：PERIOC LTD

  公开号：US20150313959A1

  公开（公告）日：2015-11-05

  The present invention relates to novel treatments of periodontal disease by administering a suitable formulation of a cyclophilin inhibitor. The present invention further relates to novel pharmaceutical compositions containing said cyclophilin inhibitor compounds.
• US9382295B2
  申请人：——

  公开号：US9382295B2

  公开（公告）日：2016-07-05
• [EN] NOVEL PHARMACEUTICAL FORMULATIONS AND THEIR USE IN THE TREATMENT OF PERIODONTAL DISEASE<br/>[FR] NOUVELLES FORMULATIONS PHARMACEUTIQUES ET LEUR UTILISATION DANS LE TRAITEMENT D'UNE MALADIE PARODONTALE
  申请人：PERIOC LTD

  公开号：WO2014091239A1

  公开（公告）日：2014-06-19

  The present invention relates to novel treatments of periodontal disease by administering a suitable formulation of a cyclophilin inhibitor. The present invention further relates to novel pharmaceutical compositions containing said cyclophilin inhibitor compounds.