1-[[5-[2-(1-hydroxypropan-2-yloxy)-2-methoxyethoxy]-5-oxopentanoyl]amino]propan-2-yl (1R,3R)-7-fluoro-3-[[2-[(1R,3R)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]-propylamino]-1-propoxypentyl]-2,3-dihydro-1,3-thiazole-4-carbonyl]amino]-1,2,3,4-tetrahydronaphthalene-1-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[[5-[2-(1-hydroxypropan-2-yloxy)-2-methoxyethoxy]-5-oxopentanoyl]amino]propan-2-yl (1R,3R)-7-fluoro-3-[[2-[(1R,3R)-4-methyl-3-[[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]-propylamino]-1-propoxypentyl]-2,3-dihydro-1,3-thiazole-4-carbonyl]amino]-1,2,3,4-tetrahydronaphthalene-1-carboxylate
• 化学式: C₅₄H₈₇FN₆O₁₂S
• 分子量: 1063.4
• InChiKey: LNMOKEYEGZTGCK-HJMRXCABSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  74
• 可旋转键数：
  33
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  249
• 氢给体数：
  5
• 氢受体数：
  16

文献信息

• [EN] PROTEIN-POLYMER-DRUG CONJUGATES<br/>[FR] CONJUGUÉS PROTÉINE-POLYMÈRE-MÉDICAMENT
  申请人：MERSANA THERAPEUTICS INC

  公开号：WO2014093394A1

  公开（公告）日：2014-06-19

  A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by Lp. Each occurrence of D is independently a therapeutic agent having a molecular weight < 5 kDa. LD and Lp are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer- drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.