5-[[4-[2-Hydroxy-2-(4-hydroxyphenyl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-[[4-[2-Hydroxy-2-(4-hydroxyphenyl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• 英文别名: 5-[[4-[2-hydroxy-2-(4-hydroxyphenyl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
• 化学式: C₁₈H₁₇NO₅S
• 分子量: 359.4
• InChiKey: CEJKHLVDQQMASA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
  申请人：Octeta Therapeutics, LLC

  公开号：EP3202401A1

  公开（公告）日：2017-08-09

  The present invention relates to thiazolidinedione analogues of formula (I)and pharmaceutical compositions that are useful for treating and/or preventing neurodegenerative disorders.

  本发明涉及式（I）的噻唑烷二酮类似物和药物组合物，可用于治疗和/或预防神经退行性疾病。
• [EN] PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES<br/>[FR] THIAZOLIDINEDIONES ÉPARGNANT LES PPAR ET ASSOCIATIONS POUR LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：METABOLIC SOLUTIONS DEV CO LLC

  公开号：WO2014093114A1

  公开（公告）日：2014-06-19

  The present invention relates to PPARy- sparing compounds and pharmaceutical compositions formulated with such compounds that are useful for treating, delaying the onset of, or reducing the symptoms of a neurodegenerative disorder including Huntington's disease, epilepsy, AMS, and MS.