(2S,4R)-2-methyl-5-[4-[methyl-[2-(methylamino)ethyl]carbamoyl]oxyphenyl]-4-[[2-[(1R,3R)-4-methyl-3-[[(3S,4S)-4-methyl-3-[[(2R)-1-methylpiperidine-2-carbonyl]amino]hex-1-en-2-yl]-propylamino]-1-propoxypentyl]-1,3-thiazole-4-carbonyl]amino]pentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4R)-2-methyl-5-[4-[methyl-[2-(methylamino)ethyl]carbamoyl]oxyphenyl]-4-[[2-[(1R,3R)-4-methyl-3-[[(3S,4S)-4-methyl-3-[[(2R)-1-methylpiperidine-2-carbonyl]amino]hex-1-en-2-yl]-propylamino]-1-propoxypentyl]-1,3-thiazole-4-carbonyl]amino]pentanoic acid
• 化学式: C₄₇H₇₇N₇O₇S
• 分子量: 884.2
• InChiKey: REFZJODNKREOLK-GDSDVIOPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  62
• 可旋转键数：
  28
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  194
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• [EN] PROTEIN-POLYMER-DRUG CONJUGATES<br/>[FR] CONJUGUÉS PROTÉINE-POLYMÈRE-MÉDICAMENT
  申请人：MERSANA THERAPEUTICS INC

  公开号：WO2014093394A1

  公开（公告）日：2014-06-19

  A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -LD-D, the protein based recognition-molecule being connected to the polymeric carrier by Lp. Each occurrence of D is independently a therapeutic agent having a molecular weight < 5 kDa. LD and Lp are linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer- drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions.