2-[(3S)-3-aminopyrrolidin-1-yl]-3-[1-(1-methylcyclohexyl)imidazol-4-yl]propanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[(3S)-3-aminopyrrolidin-1-yl]-3-[1-(1-methylcyclohexyl)imidazol-4-yl]propanoic acid
• 化学式: C₁₇H₂₈N₄O₂
• 分子量: 320.4
• InChiKey: MZXCQSLSLQJFRW-CFMCSPIPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  84.4
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Cycloalkyl-Substituted Imidazole Derivative
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20140178349A1

  公开（公告）日：2014-06-26

  A compound represented by the following general formula (I) or a pharmacologically acceptable salt thereof, wherein A represents a C3 to C12 cycloalkyl group which may be substituted by one to three selected from a fluoro group, a hydroxy group, a C1 to C6 alkyl group, etc; R 1 , R 2 , and R 3 each independently represent a hydrogen atom, a fluoro group, or a C1 to C6 alkyl group; R 4 represents a hydrogen atom or a prodrug group; and Y represents —CH 2 —CHR 5 —CH 2 —NHR 6 (wherein R 5 represents a hydrogen atom, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group, and R 6 represents a hydrogen atom or a prodrug group), or the like exhibits excellent TAFIa inhibitory activity and is useful as a therapeutic drug for myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, and the like.
• US9340531B2
  申请人：——

  公开号：US9340531B2

  公开（公告）日：2016-05-17