[(2R,3R)-2,5-dimethyl-6-oxo-2,3-dihydropyran-3-yl]carbamic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: [(2R,3R)-2,5-dimethyl-6-oxo-2,3-dihydropyran-3-yl]carbamic acid
• 化学式: C₈H₁₁NO₄
• 分子量: 185.18
• InChiKey: UZMAXBYXIVIVDY-PHDIDXHHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• THAILANSTATIN ANALOGS
  申请人：pH Pharma Co., Ltd.

  公开号：US20190084996A1

  公开（公告）日：2019-03-21

  The invention provides novel cytotoxic compounds and cytotoxic conjugates comprising these cytotoxic compounds and cell-binding agents. More specifically, this invention relates to novel thailanstatin A analogs, useful as cytotoxic small molecule toxins in antibody-drug conjugates (ADCs). The present invention further relates to compositions including these cytotoxic compounds and ADCs, and methods for using these toxins and ADCs to treat pathological conditions including cancer.

  该发明提供了新型细胞毒化合物和包含这些细胞毒化合物和细胞结合剂的细胞毒结合物。更具体地，本发明涉及新型的thailanstatin A类似物，可用作抗体药物结合物中的细胞毒小分子毒素。本发明还涉及包括这些细胞毒化合物和ADCs的组合物，以及使用这些毒素和ADCs治疗包括癌症在内的病理状况的方法。
• SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY
  申请人：UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION

  公开号：US20150307512A1

  公开（公告）日：2015-10-29

  The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.

  本发明提供了FR901464的新型类似物，以及一种改进的制备FR901464及其类似物的方法。这些化合物表现出抗癌活性，是治疗与RNA剪接功能障碍相关的多种疾病状态的候选药物。
• Thailanstatin analogs
  申请人：pH Pharma Co., Ltd.

  公开号：US10301319B2

  公开（公告）日：2019-05-28

  The invention provides novel cytotoxic compounds and cytotoxic conjugates comprising these cytotoxic compounds and cell-binding agents. More specifically, this invention relates to novel thailanstatin A analogs, useful as cytotoxic small molecule toxins in antibody-drug conjugates (ADCs). The present invention further relates to compositions including these cytotoxic compounds and ADCs, and methods for using these toxins and ADCs to treat pathological conditions including cancer.

  本发明提供了新型细胞毒性化合物以及包含这些细胞毒性化合物和细胞结合剂的细胞毒性共轭物。更具体地说，本发明涉及新型泰兰司他丁 A 类似物，可用作抗体-药物共轭物（ADC）中的细胞毒性小分子毒素。本发明还涉及包括这些细胞毒性化合物和 ADC 的组合物，以及使用这些毒素和 ADC 治疗包括癌症在内的病理状况的方法。
• US9771377B2
  申请人：——

  公开号：US9771377B2

  公开（公告）日：2017-09-26
• [EN] SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY<br/>[FR] SYNTHÈSE DE FR901464 ET DE SES ANALOGUES À ACTIVITÉ ANTITUMORALE
  申请人：UNIV PITTSBURGH

  公开号：WO2014100367A1

  公开（公告）日：2014-06-26

  The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.