DL-N(NH2)Leu-DL-Pro-DL-Glu-DL-xiThr-Gly-Gly-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-N(NH2)Leu-DL-Pro-DL-Glu-DL-xiThr-Gly-Gly-OH
• 英文别名: 5-[[1-[[2-(carboxymethylamino)-2-oxoethyl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-4-[[1-(2-hydrazinyl-4-methylpentanoyl)pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid
• 化学式: C₂₄H₄₁N₇O₁₀
• 分子量: 587.6
• InChiKey: TXDZPXPRQUUKHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -7.1
• 重原子数：
  41
• 可旋转键数：
  17
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  270
• 氢给体数：
  9
• 氢受体数：
  12

文献信息

• COMPOSITIONS AND METHODS THAT UTILIZE A PEPTIDE TAG THAT BINDS TO HYALURONAN
  申请人：Novartis AG

  公开号：EP2935589A1

  公开（公告）日：2015-10-28
• COMPOSITIONS AND METHODS FOR LONG ACTING PROTEINS
  申请人：Novartis AG

  公开号：EP3160990A2

  公开（公告）日：2017-05-03
• [EN] COMPOSITIONS AND METHODS THAT UTILIZE A PEPTIDE TAG THAT BINDS TO HYALURONAN<br/>[FR] COMPOSITIONS ET PROCÉDÉS QUI UTILISENT UNE ÉTIQUETTE PEPTIDIQUE QUI SE LIE AU HYALURONANE
  申请人：NOVARTIS AG

  公开号：WO2014099997A1

  公开（公告）日：2014-06-26

  The invention relates, in part, to compositions and methods that utilize a peptide tag that binds to hyaluronan (HA). The HA tag can be linked to a molecule such as a protein or nucleic acid which, when administered to the eye, results in an increase in ocular half-life and/ or mean residence time, and or a decrease in ocular clearance of the protein or nucleic acid. The invention also encompasses methods for treating ocular disease, including retinal vascular disease, by administering a protein or nucleic acid linked to an HA peptide tag.
• [EN] COMPOSITIONS AND METHODS FOR LONG ACTING PROTEINS<br/>[FR] COMPOSITIONS ET PROCÉDÉS PERMETTANT D'OBTENIR DES PROTÉINES À ACTION PROLONGÉE
  申请人：NOVARTIS AG

  公开号：WO2015198240A2

  公开（公告）日：2015-12-30

  The present invention provides peptide tags that can be linked to a therapeutic molecule in order to decrease the clearance of the therapeutic molecule from the synovial joint, thereby increasing its intra-articular half-life.
• [EN] COMPOSITIONS AND METHODS FOR LONG ACTING PROTEINS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR PROTÉINES À ACTION LONGUE
  申请人：NOVARTIS AG

  公开号：WO2015198243A2

  公开（公告）日：2015-12-30

  The present invention is based, in part, on the discovery of peptide tags that increase the half-life and/or mean residence time of proteins or nucleic acids in the eye. In certain aspects the invention peptide tags increase the half-life and/or mean residence time of antibodies and antigen binding fragments, therapeutic proteins, protein receptors, DARPins and/or aptamers in the eye.