4-(1-Cyclobutylethylamino)-7-methyl-6-(3-methylphenyl)-5-[[4-(trifluoromethyl)phenyl]methyl]pyrrolo[3,2-d]pyrimidine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 4-(1-Cyclobutylethylamino)-7-methyl-6-(3-methylphenyl)-5-[[4-(trifluoromethyl)phenyl]methyl]pyrrolo[3,2-d]pyrimidine-2-carboxylic acid
• 英文别名: 4-(1-cyclobutylethylamino)-7-methyl-6-(3-methylphenyl)-5-[[4-(trifluoromethyl)phenyl]methyl]pyrrolo[3,2-d]pyrimidine-2-carboxylic acid
• 化学式: C₂₉H₂₉F₃N₄O₂
• 分子量: 522.6
• InChiKey: NJVOPBLDDWXZHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  80
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• SUBSTITUTED PYRROLOPYRIMIDINES AS HDM2 INHIBITORS
  申请人：MACHACEK Michelle

  公开号：US20150329548A1

  公开（公告）日：2015-11-19

  The present invention provides substituted pyrrolopyrimidines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.

  本发明提供了如此描述的取代吡咯吡嘧啶或其药学上可接受的盐或溶剂。这些代表化合物可用作HDM2蛋白的抑制剂。本发明还公开了包含上述化合物的制药组合物以及使用它们治疗癌症的潜在方法。
• US9637493B2
  申请人：——

  公开号：US9637493B2

  公开（公告）日：2017-05-02
• [EN] SUBSTITUTED PYRROLOPYRIMIDINES AS HDM2 INHIBITORS<br/>[FR] PYRROLOPYRIMIDINES SUBSTITUÉES EN TANT QU'INHIBITEURS DE HDM2
  申请人：MERCK SHARP & DOHME

  公开号：WO2014100071A2

  公开（公告）日：2014-06-26

  The present invention provides substituted pyrrolopyrimidines as described herein or a pharmaceutically acceptable salt or solvate thereof. The representative compounds are useful as inhibitors of the HDM2 protein. Also disclosed are pharmaceutical compositions comprising the above compounds and potential methods of treating cancer using the same.