9H-fluoren-9-ylmethyl N-[1-[[(7S)-7-acetamido-1,2,3-tris(hydroxymethyl)-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-10-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]carbamate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 9H-fluoren-9-ylmethyl N-[1-[[(7S)-7-acetamido-1,2,3-tris(hydroxymethyl)-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-10-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]carbamate
• 化学式: C₄₆H₄₅N₃O₉
• 分子量: 783.9
• InChiKey: WYNZBWARQFVCDG-UJGAEZNTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  58
• 可旋转键数：
  13
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  184
• 氢给体数：
  6
• 氢受体数：
  9

文献信息

• Compounds
  申请人：Incanthera Limited

  公开号：US20140179592A1

  公开（公告）日：2014-06-26

  The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP proteolytic cleavage site. The compounds are useful in the treatment of cancer.
• COMPOUNDS CONTAINING A VASCULAR DISRUPTING AGENT
  申请人：Incanthera Ltd

  公开号：US20160243252A1

  公开（公告）日：2016-08-25

  The present invention relates to compounds, and pharmaceutically acceptable salts thereof, comprising a vascular disrupting agent (VDA) associated and a MMP proteolytic cleavage site. The compounds are useful in the treatment of cancer.
• Methods Of Treating Cancer Using Compounds Containing A Vascular Disrupting Agent
  申请人：Incanthera Ltd

  公开号：US20170266307A1

  公开（公告）日：2017-09-21

  The present invention relates to prodrugs of vascular disrupting agents comprising a vascular disrupting agent (VDA) associated with a MMP proteolytic cleavage site and to the use of such prodrugs in the targeted treatment of cancer.
• US9358303B2
  申请人：——

  公开号：US9358303B2

  公开（公告）日：2016-06-07
• US9937267B2
  申请人：——

  公开号：US9937267B2

  公开（公告）日：2018-04-10