4-(2-Prop-1-en-2-yloxyethyl)morpholine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(2-Prop-1-en-2-yloxyethyl)morpholine
• 英文别名: 4-(2-prop-1-en-2-yloxyethyl)morpholine
• 化学式: C₉H₁₇NO₂
• 分子量: 171.24
• InChiKey: UXKZXIZUVNOYTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PHOTOACTIVATABLE CAGED TAMOXIFEN AND TAMOXIFEN DERIVATIVE MOLECULES AND METHODS OF USE THEREOF
  申请人：Dana-Farber Cancer Institute, Inc.

  公开号：US20150093365A1

  公开（公告）日：2015-04-02

  Provided herein are compositions containing photoactivatable caged tamoxifen and tamoxifen derivative molecules. Also provided are kits containing one of these compositions and a light source. Also provided are methods of optically inducing nuclear translocation of a fusion protein containing a mammalian estrogen receptor ligand binding domain in a eukaryotic cell and methods of optically inducing recombination in a eukaryotic cell that include contacting a eukaryotic cell with at least one of these compositions. Also provided are methods of treating breast cancer in a subject that include administering a photoactivatable caged tamoxifen or tamoxifen derivative molecule to a subject having breast cancer.

  本文提供了含有光活性遮蔽型他莫昔芬和他莫昔芬衍生物分子的组合物。还提供了包含其中一种组合物和光源的套件。本文还提供了一种在真核细胞中光学诱导含哺乳动物雌激素受体配体结合域的融合蛋白的核转运的方法以及一种包括与至少一种这些组合物接触的真核细胞中光学诱导重组的方法。本文还提供了一种治疗乳腺癌的方法，包括向患有乳腺癌的受试者给予光活性遮蔽型他莫昔芬或他莫昔芬衍生物分子。
• US9687548B2
  申请人：——

  公开号：US9687548B2

  公开（公告）日：2017-06-27
• [EN] PRMT5 INHIBITORS AND USES THEREOF<br/>[FR] INHIBITEURS DE PRMT5 ET LEURS UTILISATIONS
  申请人：EPIZYME INC

  公开号：WO2014100719A2

  公开（公告）日：2014-06-26

  Described herein are compounds of Formula (A), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5 mediated disorders are also described.