[(Z)-5-[[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R)-4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]-7,7-dimethyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] morpholine-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: [(Z)-5-[[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R)-4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]-7,7-dimethyl-1,6-dioxaspiro[2.5]octan-5-yl]-3-methylpenta-2,4-dienyl]-2,5-dimethyloxan-3-yl]amino]-5-oxopent-3-en-2-yl] morpholine-4-carboxylate
• 化学式: C39H63N5O11
• 分子量: 777.9
• InChiKey: HGLPDMUOXLAFAX-UPOKULOESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  55
• 可旋转键数：
  22
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  150
• 氢给体数：
  1
• 氢受体数：
  13

文献信息

• [EN] SYNTHESIS OF FR901464 AND ANALOGS WITH ANTITUMOR ACTIVITY<br/>[FR] SYNTHÈSE DE FR901464 ET DE SES ANALOGUES À ACTIVITÉ ANTITUMORALE
  申请人：UNIV PITTSBURGH

  公开号：WO2014100367A1

  公开（公告）日：2014-06-26

  The present invention provides novel analogs of FR901464, as well as an improved methodology for preparing FR901464 and its analogs. These compounds display an anti-cancer activity and are candidates for therapies against a number of disease states associated with dysfunctional RNA splicing.