2-(4-bromophenyl)-N-(p-tolyl)acetamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-bromophenyl)-N-(p-tolyl)acetamide
• 英文别名: (4-bromo-phenyl)-acetic acid p-toluidide；(4-Brom-phenyl)-essigsaeure-p-toluidid；2-(4-bromophenyl)-N-(4-methylphenyl)acetamide
• 化学式: C₁₅H₁₄BrNO
• mdl: MFCD02577230
• 分子量: 304.186
• InChiKey: KDEZYHDQERUVGZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对溴苯甲醛 在 三氟化硼乙醚 、 potassium hydroxide 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 反应 10.5h， 生成 2-(4-bromophenyl)-N-(p-tolyl)acetamide
  参考文献：
  名称：

  BF3·OEt2促进串联的Meinwald重排和环氧乙烷腈的亲核取代。

  摘要：

  实现了串联的梅因瓦尔德重排和亲核取代的环氧乙烷腈。在微波辐射下，在三氟化硼的存在下，由3-芳基环氧乙烷-2-甲腈与胺，醇或水容易地合成丙烯酸酯衍生物，设计的合成策略包括将氰基离去基团引入芳基环氧化物中并捕获原位生成的化合物。有毒的氰化物与三氟化硼，使反应高效，安全且对环境无害。该反应通过酸促进的Meinwald重排发生，产生芳基乙酰基氰化物，然后与含氮或氧的亲核胺，醇或水进行加成-消除过程。当前方法为串联Meinwald重排提供了新的应用。

  DOI：

  10.1039/c9ob02428j

文献信息

• Iodine deficiency in Calabria: Characterization of endemic goiter and analysis of different indicators of iodine status region-wide
  作者：G. Costante、L. Grasso、E. Schifino、M. F. Marasco、U. Crocetti、C. Capula、R. Chiarella、O. Ludovico、M. Nocera、G. Parlato、S. Filetti

  DOI：10.1007/bf03343991

  日期：2002.3

  The distribution of goiter prevalence in schoolchildren (no.=13,984, age 6-14 yr), the neonatal TSH results obtained from the congenital hypothyroidism screening program and the urinary iodine excretion values (no.=284) were employed for the assessment of iodine deficiency in Calabria, a Southern Italy region. Data were collected during the years 1990-1996. In the inland territory, goiter prevalence ranged from 19 to 64%. At sea level, there was a great variability of goiter prevalence, with values varying from 5.3 to 25.7%. The analysis of the neonatal hypothyroidism screening program data (no.=21,078) showed a 14.8% frequency of TSH levels >5 muU/ml whole blood in newborns from the inland territory and a 14.1% frequency at sea level. Urinary iodine excretion resulted (mean+/-SD) 53.8+/-43.4 mug/l (range: <20 to 189 mu g/1) in the inland territory and 89.6+/-59.8 mu g/l (range: 26 to 333 mu g/l) at sea level. Median urinary iodine excretion values in 13 villages or small towns of the inland territory ranged from 31 to 57 mu g/l. In 2 major towns located at sea level, the median iodine excretion values were 72 mu g/l in Crotone main city and 94 mu g/l in Reggio Calabria main city. The data indicated that moderate, with pockets of severe iodine deficiency is present in the inland region while iodine supply varies from sufficient to marginally low in the coastal areas. Mild iodine deficiency was found in a major town located at sea level.