[Ethoxy(methyl)phosphoryl]sulfanylmethyl propanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [Ethoxy(methyl)phosphoryl]sulfanylmethyl propanoate
• 英文别名: [ethoxy(methyl)phosphoryl]sulfanylmethyl propanoate
• 化学式: C₇H₁₅O₄PS
• 分子量: 226.23
• InChiKey: MRJFIVBLTKEZQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  77.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• SULFURIZATION REAGENTS ON SOLID SUPPORTS
  申请人：Mazur Wieslaw Adam

  公开号：US20140179875A1

  公开（公告）日：2014-06-26

  Described herein are novel solid-supported sulfurization reagents having the general structure: (I) wherein (P) is a polymer; X is a linker; R 1 is an alkyl group, a cycloalkyl group, an aryl group, or a heterocycle; and R 2 is an alkyl group, an aryl group, a methyleneacyloxy group having the formula —CH 2 —O—C(O)—R 7 , a methylene carbonate group having the formula —CH 2 —O—C(O)—OR 8 , or a methylene carbamate group having the formula —CH 2 —O—C(O)—NR 9 R 10 , wherein R 7 is a C 1 to C 20 hydrocarbon residue, R 8 is any alkyl, cycloalkyl, aryl, or heteroaryl, and R 9 and R 10 are independently hydrogen, alkyl, cycloalkyl, aryl, or heteroaryl. Other embodiments include solid-supported sulfurization reagents having the structure of Formula I, wherein (P) is a polystyrene-based solid support and X is an aromatic linker. Also described herein are methods for synthesizing the solid-supported sulfurization reagents and their use during the synthesis of oligonucleotides.

  本文描述了一种新型固体支持硫化试剂，其具有以下通用结构：(I)，其中(P)是聚合物；X是连接剂；R1是烷基、环烷基、芳基或杂环基；R2是烷基、芳基、具有公式—CH2—O—C(O)—R7的亚甲基酰氧基、具有公式— —O—C(O)—OR8的亚甲基碳酸基或具有公式— —O—C(O)—NR9R10的亚甲基氨基甲酸酯基，其中R7是C1到C20碳氢残基，R8是任何烷基、环烷基、芳基或杂芳基，R9和R10独立地为氢、烷基、环烷基、芳基或杂芳基。其他实施例包括具有式I结构的固体支持硫化试剂，其中(P)是基于聚苯乙烯的固体支持，X是芳香连接剂。本文还描述了制备固体支持硫化试剂的方法以及它们在寡核苷酸合成过程中的应用。