Ethyl 4-(3-cyano-6-fluoro-5-propan-2-yloxyindol-1-yl)benzoate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: Ethyl 4-(3-cyano-6-fluoro-5-propan-2-yloxyindol-1-yl)benzoate
• 英文别名: ethyl 4-(3-cyano-6-fluoro-5-propan-2-yloxyindol-1-yl)benzoate
• 化学式: C₂₁H₁₉FN₂O₃
• 分子量: 366.4
• InChiKey: SKMXKUUEDIGUBW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  64.2
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
  申请人：KISSEI PHARMACEUTICAL CO., LTD.

  公开号：US20140179932A1

  公开（公告）日：2014-06-26

  The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH 2 , halogen, nitro, alkyl, alkoxy and the like; X 1 , X 2 and X 3 independently represent CR 2 or N; R 1 and R 2 independently represent halogen, cyano, haloalkyl, A-D-E-G, —N(-D-E-G) 2 and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO 2 and the like.

  本发明提供了化合物，其可用作预防或治疗与异常血清尿酸水平相关的疾病的药剂，具有尿酸排泄活性或类似活性。本发明涉及以下通式（I）所表示的（氮）吲哚衍生物，具有黄嘌呤氧化酶抑制活性，可用作预防或治疗与血清尿酸水平异常相关的疾病的药剂，其前药或盐。在式（I）中，T表示硝基或氰基等；环J表示芳基或杂芳基等；Q表示羧基或5-四唑基等；Y表示H、OH、NH2、卤素、硝基、烷基、烷氧基等；X1、X2和X3独立地表示CR2或N；R1和R2独立地表示卤素、氰基、卤代烷基、A-D-E-G、-N（-D-E-G）2等，在式中，A表示单键、O、S等；D和G独立地表示可选的取代基的烷基、环烷基、杂环烷基、芳基、杂芳基等；E表示单键、O、S、COO、SO2等。
• US8829040B2
  申请人：——

  公开号：US8829040B2

  公开（公告）日：2014-09-09