2-Imino-3-methylpentanamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Imino-3-methylpentanamide
• 英文别名: 2-imino-3-methylpentanamide
• 化学式: C₆H₁₂N₂O
• 分子量: 128.17
• InChiKey: QOGWNFHDTKFJIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  66.9
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• [EN] PEPTIDES AS OXYTOCIN AGONISTS<br/>[FR] PEPTIDES EN TANT QU'AGONISTES DE L'OXYTOCINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014095773A1

  公开（公告）日：2014-06-26

  The invention relates to compounds of formula (I) wherein R1 is hydroxy or amino; R2 is sec-butyl or isobutyl; R3 is lower alkyl, lower alkyl substituted by hydroxy, -(CH2)2C(O)-NH2, -(CH2)3-NH2 or -CH2-five membered aromatic heterocyclic group; R4 is hydrogen or lower alkyl; R5 is hydrogen or lower alkyl; or R4 and R5 may form together with the N and C atom to which they are attached a pyrrolidine ring optionally substituted by hydroxy or halogen, a piperidine ring or an azetidine ring; R6 is hydrogen, lower alkyl, lower alkyl substituted by hydroxy, -(CH2)2C(O)OH, -(CH2)2C(O)NH2, benzyl optionally substituted by amino or hydroxy, -CH2-five membered aromatic heterocyclic group, indolyl, -CH2-cycloalkyl, cycloalkyl, -(CH2)2-S- lower alkyl or is -(CH2)1-4-NH2; R6' is hydrogen or lower alkyl; or R6 and R6' are together cycloalkyl; X is -C(O)-CHR-NR'-C(O)-; R/R' are independently from each other hydrogen or lower alkyl; m is 2; O is 0 or 1; or a to pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. It has been found that the present compounds are oxytocin receptor agonists for the treatment of autism, stress, including post traumatic stress disorder, anxiety, including anxiety disorders and depression, schizophrenia, psychiatric disorders and memory loss, alcohol withdrawel, drug addiction and for the treatment of Prader-Willi Syndrom.
• [EN] PRE-ACTIVATED NUCLEOSIDE IMPDH INHIBITORS AS ANTI-INFECTIVE DRUGS<br/>[FR] INHIBITEURS NUCLÉOSIDIQUES D'IMPDH PRÉ-ACTIVÉS EN TANT QUE MÉDICAMENTS ANTI-INFECTIEUX
  申请人：OCTAGON THERAPEUTICS INC

  公开号：WO2020072931A2

  公开（公告）日：2020-04-09

  The present disclosure provides inosine-5'-monophosphate dehydrogenase (IMPDH)-inhibiting nucleoside derivatives having anti-infective activities, and methods of their synthesis and use.