(2,3-Dihydroxy-3-methylbutanoyl) 2-hydroxy-2-methyl-3-oxobutanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 酮酸及其衍生物
• 英文名称: (2,3-Dihydroxy-3-methylbutanoyl) 2-hydroxy-2-methyl-3-oxobutanoate
• 英文别名: (2,3-dihydroxy-3-methylbutanoyl) 2-hydroxy-2-methyl-3-oxobutanoate
• 化学式: C₁₀H₁₆O₇
• 分子量: 248.23
• InChiKey: WBGWQYUAHGMCTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  121
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• TRANSFORMANT OF CORYNEFORM BACTERIUM AND METHOD FOR PRODUCING VALINE BY USING SAME
  申请人：Research Institute Of Innovative Technology For The Earth

  公开号：EP2749638A1

  公开（公告）日：2014-07-02

  A transformant obtainable by introducing one or more of the following DNAs (a), (b), and (c) into a coryneform bacterium as a host. (a) A DNA which encodes acetohydroxy acid synthase derived from Corynebacterium glutamicum and which has a mutation changing the glycine at position 156 to glutamic acid (G156E) in an amino acid sequence encoded by the DNA, or an analog thereof. (b) A DNA which encodes acetohydroxy acid isomeroreductase derived from Corynebacterium glutamicum and which has mutations changing the serine at position 34 to glycine (S34G), the leucine at position 48 to glutamic acid (L48E), and the arginine at position 49 to phenylalanine (R49F) in an amino acid sequence encoded by the DNA, or an analog thereof. (c) A DNA which encodes leucine dehydrogenase derived from Lysinibacillus sphaericus, or an analog thereof.

  将下列 DNA（a）、（b）和（c）中的一种或多种引入作为宿主的棒状杆菌，可获得转化体。 (a) 一种 DNA，它编码来自谷氨酸棒杆菌的乙酰羟酸合成酶，该 DNA 或其类似物编码的氨基酸序列中 156 位的甘氨酸突变为谷氨酸（G156E）。 (b) 一种 DNA，它编码来自谷氨酸棒杆菌的乙酰羟酸异构还原酶，该 DNA 编码的氨基酸序列中，34 位丝氨酸突变为甘氨酸（S34G），48 位亮氨酸突变为谷氨酸（L48E），49 位精氨酸突变为苯丙氨酸（R49F），或其类似物。 (c) 一种 DNA，其编码的亮氨酸脱氢酶来自 Lysinibacillus sphaericus，或其类似物。
• Coryneform Bacterium Transformant and Process for Producing Valine Using the Same
  申请人：Yukawa Hideaki

  公开号：US20140227747A1

  公开（公告）日：2014-08-14

  A transformant obtainable by introducing one or more of the following DNAs (a), (b), and (c) into a coryneform bacterium as a host. (a) A DNA which encodes acetohydroxy acid synthase derived from Corynebacterium glutamicum and which has a mutation changing the glycine at position 156 to glutamic acid (G156E) in an amino acid sequence encoded by the DNA, or an analog thereof. (b) A DNA which encodes acetohydroxy acid isomeroreductase derived from Corynebacterium glutamicum and which has mutations changing the serine at position 34 to glycine (S34G), the leucine at position 48 to glutamic acid (L48E), and the arginine at position 49 to phenylalanine (R49F) in an amino acid sequence encoded by the DNA, or an analog thereof. (c) A DNA which encodes leucine dehydrogenase derived from Lysinibacillus sphaericus , or an analog thereof.
• US8975049B2
  申请人：——

  公开号：US8975049B2

  公开（公告）日：2015-03-10
• US9290770B2
  申请人：——

  公开号：US9290770B2

  公开（公告）日：2016-03-22