2-[6-(ethylthio)pyridazin-3-yl]-2-phenylacetonitrile | 1159497-77-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-[6-(ethylthio)pyridazin-3-yl]-2-phenylacetonitrile
• 英文别名: 2-(6-Ethylsulfanylpyridazin-3-yl)-2-phenylacetonitrile
• CAS: 1159497-77-4
• 化学式: C₁₄H₁₃N₃S
• 分子量: 255.343
• InChiKey: WLRNSLKFPNCIGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  74.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-[6-(ethylthio)pyridazin-3-yl]-2-phenylacetonitrile 在 吡啶 、 ammonium polysulfide 作用下， 以 1,4-二氧六环 为溶剂， 反应 12.0h， 以70%的产率得到2-(6-Ethylsulfanylpyridazin-3-yl)-2-phenylethanethioamide
  参考文献：
  名称：

  Synthesis, Fungicidal and Antibacterial Activity of New Pyridazine Derivatives

  摘要：

  Compounds 1 - 3 were obtained in the reaction of 3,6-dichloropyridazines with phenylacetonitriles in the biphasic system - DMSO / 50% NaOH. The chlorine atom was replaced with cycloalkylamino (4 - 13) and hydrazinyl (23, 24) moiety. These last compounds were condensed with aldehydes (25 - 34). Pyridazynylphenylacetonitriles were converted into amides 14 - 18 and thioamides 19 - 22. In compounds 2, 3 the chlorine atom was replaced with thiophenyl (37, 38) and in compound 1 with thioethyl and thiophenyl (35, 36) functional groups. In the reactions of compounds 1, 2 with ammonium polysulfide thioamides with thiol group (39, 40) and chlorine atom (41, 42) were obtained. Compounds 1 - 17, 19 43 were screened for antibacterial and fungicidal activities.

  DOI：

  10.3987/com-08-11577
• 作为产物：
  描述：

  6-氯-α-苯基-3-哒嗪乙酰腈 、 乙硫醇 在 sodium 作用下， 以 1,4-二氧六环 为溶剂， 反应 5.0h， 以65%的产率得到2-[6-(ethylthio)pyridazin-3-yl]-2-phenylacetonitrile
  参考文献：
  名称：

  Synthesis, Fungicidal and Antibacterial Activity of New Pyridazine Derivatives

  摘要：

  Compounds 1 - 3 were obtained in the reaction of 3,6-dichloropyridazines with phenylacetonitriles in the biphasic system - DMSO / 50% NaOH. The chlorine atom was replaced with cycloalkylamino (4 - 13) and hydrazinyl (23, 24) moiety. These last compounds were condensed with aldehydes (25 - 34). Pyridazynylphenylacetonitriles were converted into amides 14 - 18 and thioamides 19 - 22. In compounds 2, 3 the chlorine atom was replaced with thiophenyl (37, 38) and in compound 1 with thioethyl and thiophenyl (35, 36) functional groups. In the reactions of compounds 1, 2 with ammonium polysulfide thioamides with thiol group (39, 40) and chlorine atom (41, 42) were obtained. Compounds 1 - 17, 19 43 were screened for antibacterial and fungicidal activities.

  DOI：

  10.3987/com-08-11577

文献信息

• Synthesis, Fungicidal and Antibacterial Activity of New Pyridazine Derivatives
  作者：Henryk Foks、Krystyna Wisterowicz、Agnieszka Miszke、Kamil Brożewicz、Katarzyna Wiśniewska、Maria Dąbrowska-Szponar

  DOI：10.3987/com-08-11577

  日期：——

  Compounds 1 - 3 were obtained in the reaction of 3,6-dichloropyridazines with phenylacetonitriles in the biphasic system - DMSO / 50% NaOH. The chlorine atom was replaced with cycloalkylamino (4 - 13) and hydrazinyl (23, 24) moiety. These last compounds were condensed with aldehydes (25 - 34). Pyridazynylphenylacetonitriles were converted into amides 14 - 18 and thioamides 19 - 22. In compounds 2, 3 the chlorine atom was replaced with thiophenyl (37, 38) and in compound 1 with thioethyl and thiophenyl (35, 36) functional groups. In the reactions of compounds 1, 2 with ammonium polysulfide thioamides with thiol group (39, 40) and chlorine atom (41, 42) were obtained. Compounds 1 - 17, 19 43 were screened for antibacterial and fungicidal activities.