1-methylthio-N-phenylpropane-2-amine | 80865-95-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-methylthio-N-phenylpropane-2-amine
• 英文别名: N-<2-(Methylthio)isopropyl>aniline；methyl 2-(phenylamino)propyl sulfide；N-(1-methylsulfanylpropan-2-yl)aniline
• CAS: 80865-95-8
• 化学式: C₁₀H₁₅NS
• 分子量: 181.302
• InChiKey: WQRKCGMTIZVRQH-UHFFFAOYSA-N

物化性质

• 沸点：
  64-65 °C(Press: 0.001 Torr)
• 密度：
  1.049±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-methylthio-N-phenylpropane-2-amine 在 重水 作用下， 反应 3.0h， 生成 1,3-dideuterio-N-phenylpropan-2-amine 、 1,3-bis(methylthio)-N-phenylpropane-2-amine 、 1-deuterio-N-phenyl-3-methylthiopropane-2-amine
  参考文献：
  名称：

  Barluenga, Jose; Fananas, Francisco J.; Villamana, Jorge, Journal of the Chemical Society. Perkin transactions I, 1984, p. 2685 - 2692

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-1-苯基氮丙啶 、 二甲基二硫 在 萘 、 lithium 作用下， 以 四氢呋喃 为溶剂， 以73%的产率得到1-methylthio-N-phenylpropane-2-amine
  参考文献：
  名称：

  N,2-Dilithioalkylamines from Aziridines by Naphthalene-Catalyzed Reductive Opening. Synthetic Applications

  摘要：

  The reductive opening of aziridines 1a-c with lithium in the presence of a catalytic amount of naphthalene at -78 degrees C led to the corresponding dianionic intermediates 2a-c, which are stable species under these reaction conditions and react with electrophilic reagents [H2O, D2O, Me(2)S(2), Bu(t)CHO, PhCHO, Me(2)CO, (CH2)(5)CO, (EtO)(2)CO, CH2=CHCO(2)Me, PhCON(CH2)(4), PhCH=NPh, MeI, and CH2=CHCH2Br] to give, after hydrolysis with water, the corresponding difunctionalized compounds 3-5. When the reductive opening and the reaction with electrophiles [H2O, D2O, CH2=CHCH2Br, Me(2)CO, (c-C3H5)(2)CO] were carried out on chiral aziridines 8 and 9, enantiomerically pure difunctionalized compounds 12 were obtained with same stereochemistry, independently of the stereochemistry of diastereomeric starting aziridines 8 and 9.

  DOI：

  10.1021/jo00090a044

文献信息

• Phthalamide derivatives, or salt thereof agrohorticultural insecticide, and method for using the same
  申请人：NIHON NOHYAKU CO., LTD.

  公开号：EP1006107A2

  公开（公告）日：2000-06-07

  The present invention provides a phthalamide derivative of the formula (I): [wherein A1 is (substituted) C1-C8 alkylene, (substituted) C3-C8 alkenylene, (substituted) C3-C8 alkynylene, etc., R1 is H, (halo) C3-C6 cycloalkyl, (substituted) phenyl, (substituted) heterocycle, -A2-R4, etc., R2 and R3 are H, C3-C6 cycloalkyl, -A2-R4, etc., A2 is -C(=O)-, -C(=S)- or -C(=NR5)-, R4 is H, alkyl, (substituted) phenyl, (substituted) heterocycle, etc., X and Y are halogen, cyano, nitro, (halo) C1-C6 alkyl, (halo) C1-C6 alkoxy, etc., 1 is 0-4, m is 0-5, n is 0-2]; and an agrohorticultural insecticide containing said compound as active ingredient and exhibiting an excellent insecticidal effect.

  本发明提供了一种式（I）的邻苯二甲酰胺衍生物： [其中 A1 是（取代）C1-C8 亚烷基、（取代）C3-C8 烯基、（取代）C3-C8 亚炔基等，R1 是 H、（卤代）C3-C6 环烷基、（取代）苯基、（取代）杂环、-A2-R4 等，R2 和 R3 是 H、C3-C6 环烷基、-A2-R4 等、A2是-C(＝O)-、-C(＝S)-或-C(＝NR5)-，R4是H、烷基、（取代的）苯基、（取代的）杂环等，X和Y是卤素、氰基、硝基、（卤代）C1-C6烷基、（卤代）C1-C6烷氧基等，1是0-4，m是0-5，n是0-2]；以及一种含有上述化合物作为活性成分并具有优异杀虫效果的农用园艺杀虫剂。
• .beta.-Substituted organolithium compounds. Reaction with alkyl halides, dimethyl disulfide, and imines
  作者：Jose Barluenga、Francisco J. Fananas、Jorge Villamana、Miguel Yus

  DOI：10.1021/jo00347a037

  日期：1982.4
• BARLUENGA, J.;FANANAS, F. J.;VILLAMANA, J.;YUS, M., J. ORG. CHEM., 1982, 47, N 8, 1560-1564
  作者：BARLUENGA, J.、FANANAS, F. J.、VILLAMANA, J.、YUS, M.

  DOI：——

  日期：——
• BARLUENGA, J.;FANANAS, F. J.;VILLAMANA, J.;YUS, M., J. CHEM. SOC. PERKIN TRANS., 1984, N 12, 2685-2692
  作者：BARLUENGA, J.、FANANAS, F. J.、VILLAMANA, J.、YUS, M.

  DOI：——

  日期：——
• US6603044B1
  申请人：——

  公开号：US6603044B1

  公开（公告）日：2003-08-05