(4Z,8E,10E,12R,14Z,16E,18R)-5,12,18-trihydroxyicosa-4,8,10,14,16-pentaenoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (4Z,8E,10E,12R,14Z,16E,18R)-5,12,18-trihydroxyicosa-4,8,10,14,16-pentaenoic acid
• 化学式: C₂₀H₃₀O₅
• 分子量: 350.4
• InChiKey: MACPVBBVSPYNTP-ISBCGERXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  98
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• CD11B- LOW MACROPHAGES AND CONDITIONED MEDIA THEREOF FOR TREATING CANCER AND/OR FIBROSIS
  申请人：Carmel-Haifa University Economic Corporation Ltd

  公开号：EP2941256B1

  公开（公告）日：2020-05-06
• CD11b- low MACROPHAGES AND CONDITIONED MEDIA THEREOF FOR TREATING CANCER AND/OR FIBROSIS
  申请人：Carmel-Haifa University Economic Corporation Ltd

  公开号：EP2941256A1

  公开（公告）日：2015-11-11
• CD11 B[low] MACROPHAGES AND CONDITIONED MEDIA THEREOF FOR TREATING CANCER AND/OR FIBROSIS
  申请人：CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD

  公开号：US20170340670A1

  公开（公告）日：2017-11-30

  A conditioned cell culture medium of CD11b low human macrophages or a biologically active fraction thereof can be prepared by a method that includes (i) culturing a population of human mononuclear cells of the monocyte/macrophage lineage for 5-7 days, so as to induce differentiation of the mononuclear cells to macrophages; (ii) incubating the macrophages obtained in (i) with apoptotic cells or in the presence of a pro-resolving lipid mediator to reduce the CD11b expression, thus obtaining a culture of CD11b low macrophages; and (iii) collecting the conditioned cell culture medium of CD11b low macrophages. Pharmaceutical compositions containing the CD11b low macrophages conditioned medium or a culture of CD11b low macrophages can be used in the treatment of cancer or fibrosis.
• [EN] CD11blow MACROPHAGES AND CONDITIONED MEDIA THEREOF FOR TREATING CANCER AND/OR FIBROSIS<br/>[FR] MACROPHAGES FAIBLES EN CD11B ET LEURS MILIEUX CONDITIONNÉS PERMETTANT DE TRAITER LE CANCER ET/OU LA FIBROSE
  申请人：UNIV CARMEL HAIFA ECONOMIC COR

  公开号：WO2014102799A1

  公开（公告）日：2014-07-03

  A conditioned medium of CD11blow macrophages and methods for preparing it are provided. Pharmaceutical compositions comprising the CD11blow macrophages conditioned medium or a culture of CD11blow macrophages and their use in the treatment of cancer or fibrosis are also provided.