5-chloro-3-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 5-chloro-3-[[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide
• 化学式: C₁₉H₁₈ClN₃O₅S
• 分子量: 435.9
• InChiKey: UYVLHOLCINCRFV-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  130
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• ALDEHYDE DERIVATIVE OF SUBSTITUTE OXAZOLIDINONES
  申请人：Wanbury Limited

  公开号：EP2897619A2

  公开（公告）日：2015-07-29
• [EN] ALDEHYDE DERIVATIVE OF SUBSTITUTE OXAZOLIDINONES<br/>[FR] DÉRIVÉ ALDÉHYDE D'OXALIDINONES SUBSTITUÉES
  申请人：WANBURY LTD

  公开号：WO2014102822A2

  公开（公告）日：2014-07-03

  The present invention concern towards the prodrug of 5-chloro-N-((5S)-2-oxo-3-[4-(3- oxo-morpholin-4-yl)phenyl]-l,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide, rivaroxaban per se; processes for their preparation, and the application in treatment and/or prophylaxis of diseases, especially of thromboembolic disorders. The prodrug of compound formula (B) is chemically designated as5-chloro-N-formyl-N-((5S)-2-oxo-3-[4-(3- oxomorpholin-4-yl)phenyl]- l,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide.(I)