6-[[2-Amino-5-[[5-carboxy-5-[carboxymethyl-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]amino]pentyl]amino]-5-oxopentanoyl]amino]-2,3-ditert-butyl-2-[(3-carboxy-2,2,4,4-tetramethylpentan-3-yl)-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]amino]hexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 6-[[2-Amino-5-[[5-carboxy-5-[carboxymethyl-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]amino]pentyl]amino]-5-oxopentanoyl]amino]-2,3-ditert-butyl-2-[(3-carboxy-2,2,4,4-tetramethylpentan-3-yl)-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]amino]hexanoic acid
• 英文别名: 6-[[2-amino-5-[[5-carboxy-5-[carboxymethyl-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]amino]pentyl]amino]-5-oxopentanoyl]amino]-2,3-ditert-butyl-2-[(3-carboxy-2,2,4,4-tetramethylpentan-3-yl)-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethyl]amino]hexanoic acid
• 化学式: C₄₉H₈₉N₅O₁₄
• 分子量: 972.3
• InChiKey: QQRXGVAWRSKKHT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  68
• 可旋转键数：
  34
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.84
• 拓扑面积：
  293
• 氢给体数：
  7
• 氢受体数：
  17

文献信息

• [EN] MOLECULAR SENSOR AND METHODS OF USE THEREOF<br/>[FR] CAPTEUR MOLÉCULAIRE ET SES PROCÉDÉS D'UTILISATION
  申请人：YEDA RES & DEV

  公开号：WO2014102803A1

  公开（公告）日：2014-07-03

  The present invention is directed to fluorescent molecular sensor based on thiazole orange as represented below for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

  本发明涉及一种基于噻唑橙的荧光分子传感器，用于蛋白质检测。本发明的分子传感器与蛋白质靶标的相互作用导致荧光发射显著增加。光输出信号的产生使得可以检测与不同疾病相关的蛋白生物标志物，或者在活细胞中检测感兴趣的蛋白质。
• MOLECULAR SENSOR AND METHODS OF USE THEREOF
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US20150276753A1

  公开（公告）日：2015-10-01

  The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

  本发明涉及一种基于Thiazole Orange的荧光分子传感器，用于蛋白质检测。本发明的分子传感器与蛋白质靶标的相互作用导致荧光发射显著增加。光输出信号的产生使得人们能够检测与不同疾病相关的蛋白质生物标志物或者在活细胞中检测感兴趣的蛋白质。
• Molecular sensor and methods of use thereof
  申请人：YEDA RESEARCH AND DEVELOPMENT CO. LTD.

  公开号：US10557853B2

  公开（公告）日：2020-02-11

  The present invention is directed to fluorescent molecular sensor based on Thiazole Orange for protein detection. Interaction of the protein target with the molecular sensors of this invention results in a significant increase in the fluorescence emission. The generation of light output signal enables one to detect protein biomarkers associated with different diseases or detecting the protein of interest also in living cells.

  本发明涉及基于噻唑橙的用于蛋白质检测的荧光分子传感器。蛋白质目标与本发明的分子传感器相互作用后，荧光发射会显著增加。光输出信号的产生使人们能够检测与不同疾病相关的蛋白质生物标记物，或在活细胞中检测感兴趣的蛋白质。
• US9696310B2
  申请人：——

  公开号：US9696310B2

  公开（公告）日：2017-07-04