2-(3-Bromopropyl)-2-propan-2-ylpropanedioic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(3-Bromopropyl)-2-propan-2-ylpropanedioic acid
• 英文别名: 2-(3-bromopropyl)-2-propan-2-ylpropanedioic acid
• 化学式: C₉H₁₅BrO₄
• 分子量: 267.12
• InChiKey: WUZFNAMBUUPOKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• SELF-ASSEMBLING ULTRASHORT PEPTIDES MODIFIED WITH BIOACTIVE AGENTS BY CLICK CHEMISTRY
  申请人：AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

  公开号：US20150352220A1

  公开（公告）日：2015-12-10

  The present invention relates to hydrogels comprising a first peptide with a covalently linked bioactive agent and optionally a second peptide. The present invention further relates to uses of the hydrogel for delivery of the bioactive agent or as an implant. The present invention further relates to drug delivery devices, implant, pharmaceutical or cosmetic compositions comprising the hydrogel. The present invention further relates to methods of local treatment of diseases and to methods for preparing the first peptide and the hydrogels.

  本发明涉及含有第一肽和共价连接的生物活性剂的水凝胶，可选地还包括第二肽。本发明还涉及使用该水凝胶作为生物活性剂的传递或作为植入物的用途。本发明还涉及药物传递装置、植入物、制药或化妆品组合物，其中包括该水凝胶。本发明还涉及局部治疗疾病的方法以及制备第一肽和水凝胶的方法。
• Self-assembling ultrashort peptides modified with bioactive agents by click chemistry
  申请人：Agency for Science, Technology and Research

  公开号：US10117946B2

  公开（公告）日：2018-11-06

  The present invention relates to hydrogels comprising a first peptide with a covalently linked bioactive agent and optionally a second peptide. The present invention further relates to uses of the hydrogel for delivery of the bioactive agent or as an implant. The present invention further relates to drug delivery devices, implant, pharmaceutical or cosmetic compositions comprising the hydrogel. The present invention further relates to methods of local treatment of diseases and to methods for preparing the first peptide and the hydrogels.

  本发明涉及一种水凝胶，该水凝胶由带有共价连接生物活性剂的第一肽和可选的第二肽组成。本发明进一步涉及该水凝胶用于递送生物活性剂或作为植入物的用途。本发明还涉及包含水凝胶的给药装置、植入物、药物或化妆品组合物。本发明还涉及局部治疗疾病的方法以及制备第一种肽和水凝胶的方法。
• [EN] SELF-ASSEMBLING ULTRASHORT PEPTIDES MODIFIED WITH BIOACTIVE AGENTS BY CLICK CHEMISTRY<br/>[FR] PEPTIDES ULTRA-COURTS À AUTO-ASSEMBLAGE MODIFIÉS PAR DES AGENTS BIOACTIFS PAR CHIMIE CLIC
  申请人：AGENCY SCIENCE TECH & RES

  公开号：WO2014104974A2

  公开（公告）日：2014-07-03

  The present invention relates to hydrogels comprising a first peptide with a covalently linked bioactive agent and optionally a second peptide. The present invention further relates to uses of the hydrogel for delivery of the bioactive agent or as an implant. The present invention further relates to drug delivery devices, implant, pharmaceutical or cosmetic compositions comprising the hydrogel. The present invention further relates to methods of local treatment of diseases and to methods for preparing the first peptide and the hydrogels.