2-(2-Hydroxypropanoyloxy)ethyl 2,2-dimethylbutanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(2-Hydroxypropanoyloxy)ethyl 2,2-dimethylbutanoate
• 英文别名: 2-(2-hydroxypropanoyloxy)ethyl 2,2-dimethylbutanoate
• 化学式: C₁₁H₂₀O₅
• 分子量: 232.27
• InChiKey: YKAPVQHMHULMJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• METHOD FOR MAKING CUSTOMISED NANOPARTICLES, NANOPARTICLES AND USES THEREOF
  申请人：ETH ZURICH

  公开号：US20140186445A1

  公开（公告）日：2014-07-03

  A method for the production of biodegradable nanoparticles with an average particle size of less than 400 nm. In a first step, a macromonomer is prepared in a ring opening polymerization process between a hydrophilic acrylate compound (A) as an initiator and hydrophobic cyclic monomers (B), wherein the macromonomer comprises at least two repetitive units based on the cyclic monomer. In a second step, this macromonomer or a mixture of macromonomers and/or commercial biocompatible monomers is polymerized, e.g. in a starved, miniemulsion or emulsion radical polymerization in water in the presence of a surfactant to the nanoparticle without necessitating additional subsequent steps for the actual production of the nanoparticles. The correspondingly made nanoparticles and uses thereof also are disclosed.