[(2S,3S,4S,8S)-3-(cyclopentanecarbonyloxy)-8-[(3-hydroxy-4-methoxypyridine-2-carbonyl)amino]-2-methyl-9-oxooxonan-4-yl] cyclopentanecarboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(2S,3S,4S,8S)-3-(cyclopentanecarbonyloxy)-8-[(3-hydroxy-4-methoxypyridine-2-carbonyl)amino]-2-methyl-9-oxooxonan-4-yl] cyclopentanecarboxylate
• 化学式: C₂₈H₃₈N₂O₉
• 分子量: 546.6
• InChiKey: AKUINVVVIBVXTM-JAKCGFMDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  39
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  150
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• MACROCYCLIC PICOLINAMIDES AS FUNGICIDES
  申请人：Dow Agrosciences LLC

  公开号：US20140187588A1

  公开（公告）日：2014-07-03

  The disclosure relates to macrocyclic picolinamides of Formula (I) and to the use of these compounds as fungicides.

  本公开涉及式(I)的宏环吡啶酰胺，以及这些化合物作为杀菌剂的使用。
• CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY
  申请人：CERULEAN PHARMA INC.

  公开号：US20140288023A1

  公开（公告）日：2014-09-25

  The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein.

  本发明涉及一种新型治疗环糊精含聚合物组合物，设计为小分子治疗药物的载体，并涉及其制药组合物。这些含环糊精的聚合物提高了药物的稳定性和溶解度，并在体内使用时降低了小分子治疗的毒性。此外，通过从各种连接剂和靶向配体中进行选择，这些聚合物提供了治疗剂的可控释放方法。本发明还涉及使用所述治疗组合物治疗受试者的方法。本发明还涉及进行制药业务的方法，包括制造、许可或分销包含或涉及所述聚合物化合物的试剂盒。
• US9681664B2
  申请人：——

  公开号：US9681664B2

  公开（公告）日：2017-06-20
• [EN] MACROCYCLIC PICOLINAMIDES AS FUNGICIDES<br/>[FR] PICOLINAMIDES MACROCYCLIQUES EN TANT QUE FONGICIDES
  申请人：DOW AGROSCIENCES LLC

  公开号：WO2014105817A1

  公开（公告）日：2014-07-03

  The disclosure relates to macrocyclic picolinamides of Formula (I) and to the use of these compounds as fungicides. The present disclosure also includes a fungicidal composition for the control or prevention of fungal attack comprising the macrocyclic picolinamides of Formula (I) and a phytologically acceptable carrier material. A method is also described for the control or prevention of fungal attack on a plant, including the steps of applying a fungicidally effective amount of one or more of the macrocyclic picolinamides of Formula (I) to at least one of the fungus, the plant, an area adjacent to the plant, and the seed adapted to produce the plant.