methyl (2S)-2-(2-chlorophenyl)-2-[2-(diethylcarbamoyloxy)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl (2S)-2-(2-chlorophenyl)-2-[2-(diethylcarbamoyloxy)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]acetate
• 化学式: C₂₁H₂₅ClN₂O₄S
• 分子量: 437.0
• InChiKey: WNJBDVLDXDOLNY-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  87.3
• 氢给体数：
  0
• 氢受体数：
  6

文献信息

• OPTICALLY ACTIVE 2-HYDROXY TETRAHYDROTHIENOPYRIDINE DERIVATIVES, PREPARATION METHOD AND USE IN MANUFACTURE OF MEDICAMENT THEREOF
  申请人：Jiangsu Vcare PharmaTech Co., Ltd.

  公开号：US20150011583A1

  公开（公告）日：2015-01-08

  Optically active 2-hydroxytetrahydrothienopyridine derivatives represented by Formula I and pharmaceutically acceptable salts, preparation method and use in the manufacture of a medicament thereof are disclosed. The pharmacodynamic experiment results show that the present compounds of Formula I are useful for inhibiting platelet aggregation. The pharmacokinetic experiment results show that the present compound of Formula I can be converted in vivo into pharmacologically active metabolites and are therefore useful for inhibiting platelet aggregation. Therefore, the present compounds are useful for the manufacture of a medicament for preventing or treating thrombosis and embolism related diseases.

  本发明公开了一种由式I表示的光学活性2-羟基四氢噻吩吡啶衍生物及其药学上可接受的盐，制备方法和用于制造药物的用途。药效学实验结果表明，式I的这些化合物对于抑制血小板聚集是有用的。药代动力学实验结果表明，式I的这些化合物可以在体内转化为药理学上活性的代谢物，因此对于抑制血小板聚集是有用的。因此，这些化合物对于制造预防或治疗与血栓形成和栓塞相关的疾病药物是有用的。
• US8772489B2
  申请人：——

  公开号：US8772489B2

  公开（公告）日：2014-07-08