Ac-Lys-Phe-Cys-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Ac-Lys-Phe-Cys-OH
• 英文别名: (2R)-2-[[(2S)-2-[[(2S)-2-acetamido-6-aminohexanoyl]amino]-3-phenylpropanoyl]amino]-3-sulfanylpropanoic acid
• 化学式: C₂₀H₃₀N₄O₅S
• 分子量: 438.5
• InChiKey: YQFHEKZBSKGFCR-ULQDDVLXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.2
• 重原子数：
  30
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  152
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• Peptide-based peroxidase inhibitors and methods of using same
  申请人：The Medical College of Wisconsin, Inc.

  公开号：EP2873675A1

  公开（公告）日：2015-05-20

  The present invention provides peptide-based peroxidase inhibitors having the formula AA1-AA2-AA3, wherein AA1 is a positively charged, negatively charged or neutral amino acid, AA2 is a redox active amino acid, and AA3 is an amino acid possessing a reducing potential such that AA3 is capable of undergoing a redox reaction with a radical of amino acid AA2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent antiinflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.

  本发明提供了具有式 AA1-AA2-AA3 的肽基过氧化物酶抑制剂，其中 AA1 是带正电、带负电或中性的氨基酸，AA2 是氧化还原活性氨基酸，AA3 是具有还原电位的氨基酸，这样 AA3 就能够与氨基酸 AA2 的自由基或其逆反或逆反类似物发生氧化还原反应。这种组合的结果是产生一种高效的过氧化物酶活性抑制剂，在多种血管疾病和损伤模型中具有强效抗炎特性。示例性三肽可有效抑制过氧化物酶介导的低密度脂蛋白氧化，增加 SCD 小鼠的血管舒张，抑制哮喘小鼠的嗜酸性粒细胞浸润和胶原沉积，抑制急性肺损伤，减少心脏缺血性损伤。
• Peptide-Based Peroxidase Inhibitors and Methods of Using Same
  申请人：Zhang Hao

  公开号：US20140194342A1

  公开（公告）日：2014-07-10

  The present invention provides peptide-based peroxidase inhibitors having the formula AA 1 -AA 2 -AA 3 , wherein AA 1 is a positively charged, negatively charged or neutral amino acid, AA 2 is a redox active amino acid, and AA 3 is an amino acid possessing a reducing potential such that AA 3 is capable of undergoing a redox reaction with a radical of amino acid AA 2 or a retro or retro-inverso analog thereof. The result of such a combination is a highly effective inhibitor of peroxidase activity that has potent anti-inflammatory properties in widely diverse models of vascular disease and injury. Exemplary tripeptides effectively inhibit peroxidase mediated LDL oxidation, increase vasodilation in SCD mice, inhibit eosinophil infiltration and collagen deposition in asthma mice, inhibit acute lung injury, and decrease ischemic injury of the heart.
• US8937039B2
  申请人：——

  公开号：US8937039B2

  公开（公告）日：2015-01-20