2-(2,4-dimethylphenylamino)-2-phenylacetic acid | 1432610-86-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2,4-dimethylphenylamino)-2-phenylacetic acid
• 英文别名: 2-(2,4-Dimethylanilino)-2-phenylacetic acid
• CAS: 1432610-86-0
• 化学式: C₁₆H₁₇NO₂
• 分子量: 255.316
• InChiKey: OQFAHHJSIXTKPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-cyclohexyl-2-(2,4-dimethylphenylamino)-2-phenylacetamide 在 盐酸 、 水 作用下， 生成 2-(2,4-dimethylphenylamino)-2-phenylacetic acid
  参考文献：
  名称：

  硼酸在水性介质中催化的Ugi三组分反应†

  摘要：

  使用醛，胺和异氰酸酯开发了B（OH）3催化的Ugi三组分反应，用于合成2-芳基氨基-2-苯基乙酰胺水。合成的2-芳基氨基-2-苯基乙酰胺通过酸水解有效地转化为α-氨基酸。

  DOI：

  10.1039/c3ra23087b

文献信息

• Nanoparticle catalyzed reaction (NPCR): ZnO-NP catalyzed Ugi-reaction in aqueous medium
  作者：Atul Kumar、Deepti Saxena、Maneesh Kumar Gupta

  DOI：10.1039/c3gc41101j

  日期：——

  The first ZnO-NP catalyzed Ugi type three-component (AB2C) reaction has been developed for the synthesis of 2-arylamino-2-phenylacetimidamide from an aldehyde, amine and isocyanide in aqueous media. This nanoparticle catalysed reaction (NPCR) is high yielding and has good atom economy as well as atom efficiency. The synthesized phenylacetimidamide yielded 2-amino-2-phenylacetamide on hydrolysis with

  已开发出第一个ZnO-NP催化的Ugi型三组分（AB 2 C）反应，用于从苯甲酸酯合成2-芳基氨基-2-苯基乙亚胺。醛， 胺和异氰化物在水性介质中。这个纳米粒子催化反应（NPCR）产率高，原子经济性好，原子效率高。合成的苯乙酰胺 屈服 2-氨基-2-苯基乙酰胺 上 水解与I 2 –SDS–水，而碱性 水解得到N-取代的α-氨基酸。
• ALBUMIN-BINDING COMPOUNDS THAT PREVENT NONENZYMATIC GLYCATION AND THAT MAY BE USED FOR TREATMENT OF GLYCATION-RELATED PATHOLOGIES
  申请人：EXOCELL, INC.

  公开号：EP1242069A2

  公开（公告）日：2002-09-25
• [EN] ALBUMIN-BINDING COMPOUNDS THAT PREVENT NONENZYMATIC GLYCATION AND THAT MAY BE USED FOR TREATMENT OF GLYCATION-RELATED PATHOLOGIES<br/>[FR] COMPOSES LIANT L'ALBUMINE QUI EMPECHENT LA GLYCATION NON ENZYMATIQUE ET QUI PEUVENT ETRE UTILISES DANS LE TRAITEMENT DE PATHOLOGIES LIEES A LA GLYCATION
  申请人：EXOCELL INC

  公开号：WO2001003684A2

  公开（公告）日：2001-01-18

  The present invention is directed to compositions, comprising substituted 2(pheryl amino) pheryl acetic acid compounds, that inhibit the nonenzymatic glycation of albumin, as well as methods of using compounds that inhibit albumin glycation for the treatment of glycation-related pathologies including renol vascular dysfunction.
• Boric acid catalyzed Ugi three-component reaction in aqueous media
  作者：Atul Kumar、Deepti Saxena、Maneesh Kumar Gupta

  DOI：10.1039/c3ra23087b

  日期：——

  B(OH)3 catalyzed Ugi three-component reaction for the synthesis of 2-arylamino-2-phenylacetamide has been developed using aldehydes, amines, and isocyanides in water. The synthesized 2-arylamino-2-phenylacetamides were efficiently converted into α-amino acid via acidic hydrolysis.

  使用醛，胺和异氰酸酯开发了B（OH）3催化的Ugi三组分反应，用于合成2-芳基氨基-2-苯基乙酰胺水。合成的2-芳基氨基-2-苯基乙酰胺通过酸水解有效地转化为α-氨基酸。