3-(1-Methyl-2,5-dioxopyrrolidin-3-yl)sulfanylpropanal

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(1-Methyl-2,5-dioxopyrrolidin-3-yl)sulfanylpropanal
• 英文别名: 3-(1-methyl-2,5-dioxopyrrolidin-3-yl)sulfanylpropanal
• 化学式: C₈H₁₁NO₃S
• 分子量: 201.25
• InChiKey: DFAKWBKRMCCISL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  79.8
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• BLOOD-BRAIN BARRIER PERMEABLE PEPTIDE COMPOSITIONS
  申请人：ICB International, Inc.

  公开号：US20140193834A1

  公开（公告）日：2014-07-10

  Blood-brain barrier permeable peptide compositions that contain variable antigen binding domains from camelid and/or shark heavy-chain only single-domain antibodies are described. The variable antigen binding domains of the peptide compositions bind to therapeutic and diagnostic biomarkers in the central nervous system, such as the amyloid-beta peptide biomarker for Alzheimer's disease. The peptide compositions contain constant domains from human IgG, camelid IgG, and/or shark IgNAR. The peptide compositions include heavy-chain only single-domain antibodies and compositions with one or more variable antigen binding domain, bound to one or more constant domains.