(2S)-2-amino-4-methylsulfanylbutanoic acid;carbonic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-4-methylsulfanylbutanoic acid;carbonic acid
• 化学式: C6H13NO5S
• 分子量: 211.24
• InChiKey: TXMDARRPQAEVRH-WCCKRBBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.37
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  146
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] STABLE INDOLE-3-PROPIONATE SALTS OF S-ADENOSYL-L-METHIONINE<br/>[FR] SELS D'INDOLE-3-PROPIONATE STABLES DE LA S-ADÉNOSYL-L-MÉTHIONINE
  申请人：HEBERT SAM E LLC

  公开号：WO2014113609A1

  公开（公告）日：2014-07-24

  Stable indole-3-propionic acid salts of S-adenosyl-L-methionine, or a pharmaceutically acceptable salt thereof, are disclosed, as well as pharmaceutical compositions comprising the indole-3-propionic acid salts, methods of using the indole-3-propionic acid salts and processes for making same.

  本发明公开了稳定的S-腺苷甲硫氨酸的吲哚-3-丙酸盐，或其药用可接受的盐，以及包含吲哚-3-丙酸盐的药物组合物，使用吲哚-3-丙酸盐的方法和制备方法。
• Compositions of oral alkaline salts and metabolic acid inducers and uses thereof
  申请人：Augusta University Research Institute, Inc.

  公开号：US11324774B2

  公开（公告）日：2022-05-10

  Compositions of alkaline salts and metabolic acid inducers and methods of use thereof are provided. The disclosed compositions may be used for stimulating vagal nerve efferent pathways, treating or preventing an inflammatory response or an autoimmune disorder, inhibiting or reducing one or more inflammatory M1 macrophages and/or one or more inflammatory neutrophils in the blood, promoting polarization of macrophages from a pro-inflammatory M1 state to an anti-inflammatory M2 state, and treating or preventing cardiovascular disease or metabolic disorders.

  本文提供了碱性盐和代谢酸诱导剂的组合物及其使用方法。所公开的组合物可用于刺激迷走神经传出通路，治疗或预防炎症反应或自身免疫性疾病，抑制或减少血液中的一种或多种炎性 M1 巨噬细胞和/或一种或多种炎性中性粒细胞，促进巨噬细胞从促炎性 M1 状态极化为抗炎性 M2 状态，以及治疗或预防心血管疾病或代谢紊乱。
• STABLE INDOLE-3-PROPIONATE SALTS OF S-ADENOSYL-L-METHIONINE
  申请人：Hebert Sam-E LLC

  公开号：EP2945959A1

  公开（公告）日：2015-11-25
• Compositions of Oral Alkaline Salts and Metabolic Acid Inducers and Uses Thereof
  申请人：Augusta University Research Institute, Inc.

  公开号：US20190231813A1

  公开（公告）日：2019-08-01

  Compositions of alkaline salts and metabolic acid inducers and methods of use thereof are provided. The disclosed compositions may be used for stimulating vagal nerve efferent pathways, treating or preventing an inflammatory response or an autoimmune disorder, inhibiting or reducing one or more inflammatory M1 macrophages and/or one or more inflammatory neutrophils in the blood, promoting polarization of macrophages from a pro-inflammatory M1 state to an anti-inflammatory M2 state, and treating or preventing cardiovascular disease or metabolic disorders.