(2E)-2-[3-(3-methoxypropylamino)cyclohex-2-en-1-ylidene]acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2E)-2-[3-(3-methoxypropylamino)cyclohex-2-en-1-ylidene]acetic acid
• 化学式: C₁₂H₁₉NO₃
• 分子量: 225.28
• InChiKey: OQTXHMOILNAZQT-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• COSMETIC AND/OR DERMATOLOGICAL COMPOSITION CONTAINING A MEROCYANINE DERIVATIVE COMPRISING SPECIFIC POLAR GROUPS CONSISTING OF HYDROXYL- AND ETHER-FUNCTIONALITIES
  申请人：Richard Herve

  公开号：US20140294743A1

  公开（公告）日：2014-10-02

  The present invention relates to a cosmetic and/or dermatological composition comprising in a physiologically acceptable medium at least one merocyanine derivative of formula (1) or (2) and/or its E,E-, E,Z- or Z,Z-geometrical isomer forms: comprising specific polar groups consisting of hydroxyl- and ether-functionalities. Another object of the present invention relates to a cosmetic process for controlling and/or improving the darkening of the skin under exposure to UV radiation and the homogeneity of the colour of the complexion which comprises the application onto the skin of a cosmetic composition as above defined. Another object of the present invention relates to a cosmetic process for protecting the keratinic materials and particularly the skin against photo-ageing which comprises the application onto the keratinic material of a cosmetic composition as above defined.

  本发明涉及一种化妆品和/或皮肤科学组合物，其在生理上可接受的介质中包含至少一种公式（1）或（2）的merocyanine衍生物及/或其E，E-，E，Z-或Z，Z-几何异构体形式：包括由羟基和醚功能团组成的特定极性基团。本发明的另一个目的涉及一种化妆过程，用于控制和/或改善皮肤在紫外线照射下的变黑和肤色均匀性，包括在皮肤上涂抹上述定义的化妆品组合物。本发明的另一个目的涉及一种化妆过程，用于保护角质素材料，特别是皮肤免受光老化的影响，包括在角质素材料上涂抹上述定义的化妆品组合物。
• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE, AN ORGANIC UVB-SCREENING AGENT AND AN ADDITIONAL ORGANIC UVA-SCREENING AGENT
  申请人：L'OREAL

  公开号：US20150366769A1

  公开（公告）日：2015-12-24

  The present invention relates to a cosmetic or dermatological composition comprising, in a physiologically acceptable support: a) at least one oily phase and b) at least one merocyanine compound of formula (1) defined hereinbelow and c) at least one organic UVB-screening agent chosen from: v) a liquid lipophilic organic UVB-screening agent vi) a hydrophilic organic UVB-screening agent vii) a triazine UVB-screening agent and viii) mixtures thereof; and d) at least one organic UVA-screening agent other than the said merocyanine compound; when the said UVB-screening agent is liquid and lipophilic, the said composition contains less than 2% by weight of cyclohexasiloxane relative to the total weight of the composition. Another subject of the present invention consists of a non-therapeutic cosmetic process for caring for and/or making up a keratin material, comprising the application, to the surface of the said keratin material, of at least one composition according to the invention as defined above. The invention also relates to a non-therapeutic cosmetic process for limiting the darkening of the skin and/or improving the colour and/or uniformity of the complexion, comprising the application, to the surface of the keratin material, of at least one composition as defined previously. The invention also relates to a non-therapeutic cosmetic process for preventing and/or treating the signs of ageing of a keratin material, comprising the application, to the surface of the keratin material, of at least one composition as defined previously.

  本发明涉及一种化妆品或皮肤科学组合物，包括在生理上可接受的载体中：a）至少一种油性相和b）至少一种公式（1）所定义的Merocyanine化合物，c）至少一种有机UVB筛选剂，其中包括：v）一种液态亲脂性有机UVB筛选剂，vi）一种亲水性有机UVB筛选剂，vii）三嗪类UVB筛选剂和viii）它们的混合物；d）除所述Merocyanine化合物之外的至少一种有机UVA筛选剂；当所述UVB筛选剂为液态和亲脂性时，所述组合物相对于组合物的总重量含有不到2％的环己二硅氧烷重量。本发明的另一个主题是非治疗性化妆过程，用于护理和/或化妆角蛋白质材料，包括将至少一种根据上述发明定义的组合物应用于所述角蛋白质材料的表面。本发明还涉及一种非治疗性化妆过程，用于限制皮肤变黑和/或改善肤色和/或均匀性，包括将至少一种如上所述的组合物应用于角蛋白质材料的表面。本发明还涉及一种非治疗性化妆过程，用于预防和/或治疗角蛋白质材料的衰老迹象，包括将至少一种如上所述的组合物应用于角蛋白质材料的表面。
• COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND AN OILY PHASE COMPRISING AT LEAST ONE SPECIFIC AMIDE COMPOUND
  申请人：L'OREAL

  公开号：US20150359718A1

  公开（公告）日：2015-12-17

  The present invention relates to a cosmetic or dermatological composition comprising, in a physiologically acceptable support: a) at least one merocyanine of formula (1) or (2). b) at least one oily phase comprising at least one amide compound of formula (I). The present invention also relates to a non-therapeutic cosmetic process for caring for and/or making up a keratin material, comprising the application, to the surface of the said keratin material, of at least one composition as defined above. The invention also relates to a non-therapeutic cosmetic process for limiting the darkening of the skin and/or improving the colour and/or uniformity of the complexion, comprising the application, to the surface of the keratin material, of at least one composition as defined previously. The invention also relates to a non-therapeutic cosmetic process for preventing and/or treating the signs of ageing of a keratin material, comprising the application, to the surface of the keratin material, of at least one composition as defined previously.

  本发明涉及一种化妆品或皮肤科学组合物，包括在生理上可接受的载体中：a) 至少一种式（1）或（2）的梅洛青素；b) 至少一种油性相，包括至少一种式（I）的酰胺化合物。本发明还涉及一种非治疗性化妆过程，用于护理和/或化妆角蛋白物质，包括将上述至少一种组合物应用于所述角蛋白物质的表面。该发明还涉及一种非治疗性化妆过程，用于限制皮肤变黑和/或改善肤色和/或肤色均匀性，包括将上述至少一种组合物应用于角蛋白物质的表面。该发明还涉及一种非治疗性化妆过程，用于预防和/或治疗角蛋白物质的衰老迹象，包括将上述至少一种组合物应用于角蛋白物质的表面。
• Photoprotective compositions comprising a dibenzoylmethane derivative, a merocyanine compound and a compound capable of accepting the triplet excited level energy of the dibenzoylmethane compound
  申请人：L'Oreal

  公开号：US11344487B2

  公开（公告）日：2022-05-31

  The present invention relates to a photoprotective composition for topical use comprising, in a cosmetically acceptable medium, at least one dibenzoylmethane derivative compound, at least one merocyanine compound and at least one compound capable of accepting the triplet excited level energy of said dibenzoylmethane derivative compound(s). The invention also relates to the use of at least one compound capable of accepting the triplet excited level energy of said dibenzoylmethane derivative compound(s), for photostabilizing with respect to UV radiation a composition comprising at least one dibenzoylmethane derivative compound and at least one merocyanine compound.

  本发明涉及一种局部使用的光保护组合物，该组合物包含在化妆品可接受的介质中的至少一种二苯甲酰甲烷衍生物化合物、至少一种美蓝化合物和至少一种能够接受所述二苯甲酰甲烷衍生物化合物的三重激发级能量的化合物。本发明还涉及至少一种能接受所述二苯甲酰甲烷衍生物化合物三重激发级能量的化合物的用途，用于使包含至少一种二苯甲酰甲烷衍生物化合物和至少一种美拉德菁化合物的组合物在紫外线辐射下光稳定。
• PHOTOPROTECTIVE COMPOSITIONS COMPRISING A DIBENZOYLMETHANE DERIVATIVE, A MEROCYANINE COMPOUND AND A COMPOUND CAPABLE OF ACCEPTING THE TRIPLET EXCITED LEVEL ENERGY OF THE DIBENZOYLMETHANE COMPOUND
  申请人：L'Oreal

  公开号：EP3644954A1

  公开（公告）日：2020-05-06