1-[2-[(2-Hydroxy-3-phenoxypropyl)amino]acetyl]pyrrole-2-carbonitrile;hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-[2-[(2-Hydroxy-3-phenoxypropyl)amino]acetyl]pyrrole-2-carbonitrile;hydrochloride
• 英文别名: 1-[2-[(2-hydroxy-3-phenoxypropyl)amino]acetyl]pyrrole-2-carbonitrile;hydrochloride
• 化学式: C16H18ClN3O3
• 分子量: 335.78
• InChiKey: NFGZQFTWEULKHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.45
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  87.3
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• NOVEL DDP-IV INHIBITORS
  申请人：DNJ Pharma Inc.

  公开号：EP2945930A1

  公开（公告）日：2015-11-25
• [EN] NOVEL DDP-IV INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE DDP-IV
  申请人：DNJ PHARMA INC

  公开号：WO2014113750A1

  公开（公告）日：2014-07-24

  The invention comprises novel inhibitors of dipeptidyl peptidase IV (DPP-IV) with beta blocker activity, pharmaceutical compositions comprising therapeutically effective amounts of novel inhibitors of DPP-IV, and novel methods of treating medical conditions are provided. The novel inhibitors of DPP-IV described herein are useful in the treatment of neurological disorders, diabetes, inflammatory disorders such as arthritis, obesity, osteoporosis, hypertension, and glaucoma of such other enumerated conditions as can be treated with inhibitors of DPP-IV and beta blockers.