N1-(4,5-dihydro-3H-1-benzazepin-2-yl)norspermine | 1253528-36-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯氮卓类
• 英文名称: N1-(4,5-dihydro-3H-1-benzazepin-2-yl)norspermine
• 英文别名: N'-[3-[3-(1,3,4,5-tetrahydro-1-benzazepin-2-ylideneamino)propylamino]propyl]propane-1,3-diamine
• CAS: 1253528-36-7
• 化学式: C₁₉H₃₃N₅
• 分子量: 331.505
• InChiKey: LNYAJVAJCCBZND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  24
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  74.5
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N1-(4,5-dihydro-3H-1-benzazepin-2-yl)norspermine 在 盐酸 作用下， 以 乙醇 为溶剂， 以75%的产率得到N1-(4,5-dihydro-3H-1-benzazepin-2-yl)norspermine tetrahydrochloride
  参考文献：
  名称：

  Targeting the Polyamine Transport System with Benzazepine- and Azepine-Polyamine Conjugates

  摘要：

  The polyamine transport system (PTS) whose activity is up-regulated in cancer cells is an attractive target for drug design. Two heterocyclic (azepine and benzazepine) systems were conjugated to various polyamine moieties through an amidine bound to afford 18 compounds which were evaluated for their affinity for the PTS and their ability to use the PTS for cell delivery. Structure-activity relationship studies and lead optimization afforded two attractive PTS targeting compounds. The azepine-spermidine conjugate 14 is a very selective substrate of the PTS that may serve as a vector for radioelements used for diagnoses or therapeutics in nuclear medicine. The nitrobenzazepine-spermine conjugate 28 is a very powerful PTS inhibitor with very low intrinsic cytotoxicity, able to prevent the growth of polyamine depleted cells in presence of exogenous polyamines.

  DOI：

  10.1021/jm1007648
• 作为产物：
  描述：

  2-Thiono-1,3,4,5-tetrahydro-2H-benzazepin 、 N,N'-双(3-氨丙基)-1,3-丙二胺 在 三乙胺 、 mercury dichloride 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以32%的产率得到N1-(4,5-dihydro-3H-1-benzazepin-2-yl)norspermine
  参考文献：
  名称：

  Targeting the Polyamine Transport System with Benzazepine- and Azepine-Polyamine Conjugates

  摘要：

  The polyamine transport system (PTS) whose activity is up-regulated in cancer cells is an attractive target for drug design. Two heterocyclic (azepine and benzazepine) systems were conjugated to various polyamine moieties through an amidine bound to afford 18 compounds which were evaluated for their affinity for the PTS and their ability to use the PTS for cell delivery. Structure-activity relationship studies and lead optimization afforded two attractive PTS targeting compounds. The azepine-spermidine conjugate 14 is a very selective substrate of the PTS that may serve as a vector for radioelements used for diagnoses or therapeutics in nuclear medicine. The nitrobenzazepine-spermine conjugate 28 is a very powerful PTS inhibitor with very low intrinsic cytotoxicity, able to prevent the growth of polyamine depleted cells in presence of exogenous polyamines.

  DOI：

  10.1021/jm1007648

文献信息

• Targeting the Polyamine Transport System with Benzazepine- and Azepine-Polyamine Conjugates
  作者：Sophie Tomasi、Jacques Renault、Bénédicte Martin、Stephane Duhieu、Virginie Cerec、Myriam Le Roch、Philippe Uriac、Jean-Guy Delcros

  DOI：10.1021/jm1007648

  日期：2010.11.11

  The polyamine transport system (PTS) whose activity is up-regulated in cancer cells is an attractive target for drug design. Two heterocyclic (azepine and benzazepine) systems were conjugated to various polyamine moieties through an amidine bound to afford 18 compounds which were evaluated for their affinity for the PTS and their ability to use the PTS for cell delivery. Structure-activity relationship studies and lead optimization afforded two attractive PTS targeting compounds. The azepine-spermidine conjugate 14 is a very selective substrate of the PTS that may serve as a vector for radioelements used for diagnoses or therapeutics in nuclear medicine. The nitrobenzazepine-spermine conjugate 28 is a very powerful PTS inhibitor with very low intrinsic cytotoxicity, able to prevent the growth of polyamine depleted cells in presence of exogenous polyamines.