benzyl methyl maleate | 105113-83-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl methyl maleate
• 英文别名: 4-O-benzyl 1-O-methyl (Z)-but-2-enedioate
• CAS: 105113-83-5
• 化学式: C₁₂H₁₂O₄
• 分子量: 220.225
• InChiKey: BMJXWTXRRZMGMV-FPLPWBNLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  benzyl methyl maleate 、 异丙醇 在 苯甲酰甲酸 作用下， 反应 72.0h， 以55%的产率得到β-carbomethoxy-γ,γ-dimethyl-γ-butyrolactone
  参考文献：
  名称：

  通过醇的选择性C–H活化–烷基化反应进行光有机催化内酯的合成

  摘要：

  选择性C–H活化是现代有机化学中日益重要的一个领域。在此，我们报告了我们在有机催化和光催化相结合方面的努力，以开发高效且选择性的可见光介导的C–H活化方案，并向大量Michael受体添加各种醇，然后进行环化反应，内酯，自然界中反复出现的基序。我们使用苯乙醛酸作为光催化剂，并用普通的家用灯泡作为光源，我们描述了醇与α，β-不饱和酯的多用途α-烷基化/内酯化，可产生高收率的产品。反应机理得到了广泛的研究。

  DOI：

  10.1039/c7gc01903c
• 作为产物：
  描述：

  顺丁烯二酸单甲酯 、 氯化苄 以53%的产率得到
  参考文献：
  名称：

  TOROSYAN, G. O.;GRIGOR, S. A.;BABAYAN, A. T., ARM. XIM. ZH., 41,(1988) N 7, S. 448-451

  摘要：

  DOI：

文献信息

• Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF-alpha converting enzyme (TACE)
  申请人：——

  公开号：US20030139388A1

  公开（公告）日：2003-07-24

  The present application describes novel cyclic hydroxamic acids of formula I: 1 or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NR 1 , and S(O) p , and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as inhibitors of matrix metalloproteinases (MMP), TNF-&agr; converting enzyme (TACE), aggrecanase or a combination thereof, pharmaceutical compositions containing the same, and methods of using the same.

  本申请描述了新型的公式I:1的环式羟羧酸，或其药用盐形式，其中环B是一个包含0-2个来自O、N、NR1和S(O)p的杂原子以及0-1个羰基的5-7元环系统，其他变量在本说明书中有定义，这些化合物可作为基质金属蛋白酶（MMP）、TNF-α转化酶（TACE）、聚集素酶或其组合的抑制剂，包含这些化合物的药物组合物，以及使用这些化合物的方法。
• Cyclic beta-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-alpha
  申请人：——

  公开号：US20020016336A1

  公开（公告）日：2002-02-07

  The present application describes novel cyclic &bgr;-amino acid derivatives of formula I: 1 or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NR a , and S(O) p , and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease and/or as TNF-&agr; inhibitors.

  本发明申请描述了新颖的环状β-氨基酸衍生物，其通式为I：1或其药学上可接受的盐形式，其中环B是含有0-2个选自O、N、NRa和S(O)p的杂原子以及0-1个羰基的5-7元环状系统，其他变量在本文中有定义，这些化合物可作为金属蛋白酶和/或TNF-α抑制剂使用。
• METHOD FOR AUTOMATICALLY INJECTING MONOMER FOR OPTICAL MATERIAL INTO MOLD
  申请人：KOC Solution Co., Ltd.

  公开号：EP3875259A1

  公开（公告）日：2021-09-08

  In the present invention, sealing tape is wrapped around the outer circumferential surface of an introduced mold, and a monomer solution is injected into a cavity formed therein, wherein the injection amount of the monomer solution can be precisely controlled by using a vision recognition system. According to a preferable embodiment, a monomer solution (S) of a monomer solution tank (10) is suctioned, in advance, into a syringe (20) capable of adjusting a capacity corresponding to a mold (M); most of the monomer solution (S), which has been injected into the syringe (20), is firstly injected into the mold (M) at a high injection flow rate or injection speed; while the residual amount of the monomer solution (S) is secondly injected at a reduced injection flow rate or injection speed, it is finally confirmed, by using a vision recognition system, whether the monomer solution (S) is filled in the mold (M); and then injection is finished.

  在本发明中，密封带被缠绕在引入模具的外圆周表面上，单体溶液被注入其中形成的空腔中，其中单体溶液的注入量可通过视觉识别系统进行精确控制。根据一个较好的实施方案，单体溶液箱（10）中的单体溶液（S）被预先抽吸到一个能够调节与模具（M）相对应容量的注射器（20）中；已注入注射器（20）的大部分单体溶液（S）首先以较高的注射流速或注射速度注入模具（M）；而剩余的单体溶液（S）则以较低的注射流速或注射速度进行二次注射，最后通过视觉识别系统确认单体溶液（S）是否已注入模具（M）；然后完成注射。
• Hardmask composition, method of forming pattern by using the hardmask composition, and hardmask formed using the hardmask composition
  申请人：Samsung Electronics Co., Ltd.

  公开号：US10685844B2

  公开（公告）日：2020-06-16

  Provided are a hardmask composition, a method of forming a pattern using the hardmask composition, and a hardmask formed using the hardmask composition. The hardmask composition includes a polar nonaqueous organic solvent and one of: i) a mixture of graphene quantum dots and at least one selected from a diene and a dienophile, ii) a Diels-Alder reaction product of the graphene quantum dots and the at least one selected from a diene and a dienophile, iii) a thermal treatment product of the Diels-Alder reaction product of graphene quantum dots and the at least one selected from a diene and a dienophile, or iv) a combination thereof.

  本文提供了一种硬掩膜组合物、一种使用硬掩膜组合物形成图案的方法，以及一种使用硬掩膜组合物形成的硬掩膜。硬掩膜组合物包括极性非水有机溶剂和以下物质之一：i) 石墨烯量子点和至少一种选自二烯烃和亲二烯烃的混合物；ii) 石墨烯量子点和至少一种选自二烯烃和亲二烯烃的 Diels-Alder 反应产物；iii) 石墨烯量子点和至少一种选自二烯烃和亲二烯烃的 Diels-Alder 反应产物的热处理产物；或 iv) 它们的组合。
• α,β-Cyclic-β-benzamido hydroxamic acids: Novel templates for the design, synthesis, and evaluation of selective inhibitors of TNF-α converting enzyme (TACE)
  作者：Gregory R. Ott、Naoyuki Asakawa、Zhonghui Lu、Rui-Qin Liu、Maryanne B. Covington、Krishna Vaddi、Mingxin Qian、Robert C. Newton、David D. Christ、James M. Traskos、Carl P. Decicco、James J.-W. Duan

  DOI：10.1016/j.bmcl.2007.11.059

  日期：2008.1

  Selective inhibitors of TNF-alpha Converting Enzyme (TACE) based on (1R,2S)-cyclopentyl, (3S,4S)-pyrrolidinyl, and (3R,4S)-tetrahydrofuranyl beta-benzamido hydroxamic acids have been synthesized and evaluated. This study has led to the discovery of novel inhibitors whose profiles include activity against TACE in an enzyme assay, potency in the suppression of LPS-stimulated TNF-alpha in human whole blood, selectivity against a panel of MMPs and oral bioavailability. (c) 2007 Elsevier Ltd. All rights reserved.