(-)-1,5-bis(2'-methoxymethoxy-1'-phenylcyclohexyloxy)-3-oxapentane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (-)-1,5-bis(2'-methoxymethoxy-1'-phenylcyclohexyloxy)-3-oxapentane
• 英文别名: (2-(Methoxymethoxy)-1-(2-(2-((2-(methoxymethoxy)-1-phenylcyclohexyl)oxy)ethoxy)ethoxy)cyclohexyl)benzene；[2-(methoxymethoxy)-1-[2-[2-[2-(methoxymethoxy)-1-phenylcyclohexyl]oxyethoxy]ethoxy]cyclohexyl]benzene
• 化学式: C₃₂H₄₆O₇
• 分子量: 542.713
• InChiKey: OKOFNYZUBZALER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  39
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  (S,S)-(+)-1-苯基环己烷-顺-1,2-二醇 在 sodium hydride 、 对甲苯磺酸 、 lithium bromide 作用下， 以 四氢呋喃 为溶剂， 反应 29.0h， 生成 (-)-1,5-bis(2'-methoxymethoxy-1'-phenylcyclohexyloxy)-3-oxapentane
  参考文献：
  名称：

  Synthesis of azophenolic crown ethers of C s symmetry incorporating cis-1-phenylcyclohexane-1,2-diol residues as a steric barrier and diastereotopic face selectivity in complexation of amines by their diastereotopic faces

  摘要：

  Azophenolic crown ethers 1 and 2 of C-s symmetry incorporating cis-1-phenylcyclohexane-1,2-diol residues as a steric barrier have been prepared. Diastereotopic face selectivity in complexation with 2-methoxyethylamine, n-propylamine and ethanolamine was examined using temperature-dependent H-1 NMR spectroscopy. Both bind ethanolamine stereoselectively to one of their diaseereotopic faces; the prediction of which diastereoisomeric complexwas preferentially formed is made on the basis of a CPK molecular-model examination ofthe complexes.

  DOI：

  10.1039/p19950001429

文献信息

• Synthesis of azophenolic crown ethers of C s symmetry incorporating cis-1-phenylcyclohexane-1,2-diol residues as a steric barrier and diastereotopic face selectivity in complexation of amines by their diastereotopic faces
  作者：Koichiro Naemura、Sachiko Takeuchi、Masaki Asada、Koji Ueno、Keiji Hirose、Yoshito Tobe、Takahiro Kaneda、Yoshiteru Sakata

  DOI：10.1039/p19950001429

  日期：——

  Azophenolic crown ethers 1 and 2 of C-s symmetry incorporating cis-1-phenylcyclohexane-1,2-diol residues as a steric barrier have been prepared. Diastereotopic face selectivity in complexation with 2-methoxyethylamine, n-propylamine and ethanolamine was examined using temperature-dependent H-1 NMR spectroscopy. Both bind ethanolamine stereoselectively to one of their diaseereotopic faces; the prediction of which diastereoisomeric complexwas preferentially formed is made on the basis of a CPK molecular-model examination ofthe complexes.