(8R,9R,15S)-15-methoxyheptadec-16-en-11,13-diyne-8,9-diol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (8R,9R,15S)-15-methoxyheptadec-16-en-11,13-diyne-8,9-diol
• 化学式: C₁₈H₂₈O₃
• 分子量: 292.4
• InChiKey: POCNRFOULDSLIT-RCCFBDPRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• [EN] REDUCTION OF TOXICITIES BY SYNTHETIC PANAXYTRIOL ANALOGS<br/>[FR] DIMINUTION DES TOXICITÉS PAR ANALOGUES DE SYNTHÈSE DU PANAXYTRIOL
  申请人：SLOAN KETTERING INST CANCER

  公开号：WO2014113635A1

  公开（公告）日：2014-07-24

  The present invention provides compounds, compositions and methods for promoting the healing of or reducing injury caused by chemical or radiation damage, minimizing deleterious effects on normal cells in cancer therapy, and treating and preventing cancer and micrometastasis. Radiation damage is caused by many radiation sources. In some embodiments, the radiation damage is caused by radiation therapy, such as cancer radiation therapy. In some embodiments, the radiation damage is caused by a nuclear accident, including a nuclear power plant accident. In some other embodiments, radiation damage is caused by, for example but not limited to, nuclear terrorism, nuclear weapons, and natural radiation, such as that from outer space or the earth.