5-甲氧基-2-(4-苯基甲氧基苯胺基)苯甲酸 | 54197-69-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-甲氧基-2-(4-苯基甲氧基苯胺基)苯甲酸
• 英文名称: 2-(4-benzyloxyphenylamino)-5-methoxybenzoic acid
• 英文别名: N-(4-benzyloxyphenyl)-5-methoxyanthranilic acid；2-[4-(Benzyloxy)anilino]-5-methoxybenzoic acid；5-methoxy-2-(4-phenylmethoxyanilino)benzoic acid
• CAS: 54197-69-2
• 化学式: C₂₁H₁₉NO₄
• 分子量: 349.386
• InChiKey: VBYUEKQLNUEHEN-UHFFFAOYSA-N

物化性质

• 沸点：
  540.4±50.0 °C(Predicted)
• 密度：
  1.262±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-甲氧基-2-(4-苯基甲氧基苯胺基)苯甲酸 在 甲基锂 作用下， 以 四氢呋喃 、 乙酸乙酯 为溶剂， 生成 1-[2-(4-benzyloxyphenylamino)-5-methoxyphenyl]ethanone
  参考文献：
  名称：

  Substituted aminophenylalkyl ketones, their preparation and use

  摘要：

  新型的下烷基2-(羟基苯胺基)苯基酮，可用作抑制脂氧合酶活性的药物，其化学式为##STR1##其中R为氢、下烷基、下烷氧基或卤素；R'为氢或下烷基；R"为氢、下烷基或卤素；Alk为下烷基。这些化合物通过对应的烷基或苄基醚的脱醚制备，而这些醚则是通过将2-(烷氧基或苄氧基苯胺基)苯甲酸与烷基锂反应制备而成。

  公开号：

  US04539429A1
• 作为产物：
  描述：

  2-溴-5-甲氧基苯甲酸 、 4-苯甲氧基苯胺盐酸盐 生成 5-甲氧基-2-(4-苯基甲氧基苯胺基)苯甲酸
  参考文献：
  名称：

  BAILEY, D. M.

  摘要：

  DOI：

文献信息

• Substituted aminobenzoates, their preparation and use
  申请人：Sterling Drug Inc.

  公开号：US04515980A1

  公开（公告）日：1985-05-07

  Novel lower-alkyl 2-(hydroxyphenylamino)benzoates, useful as inhibitors of lipoxygenase, are of the formula ##STR1## wherein R is hydrogen, lower-alkyl or lower-alkoxy; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Alk is lower-alkyl. The compounds are prepared by de-etherification of the corresponding alkyl or benzyl ethers.

  新型的下烷基2-(羟基苯胺基)苯甲酸酯，作为脂氧合酶抑制剂，其化学式为##STR1##其中R为氢、下烷基或下烷氧基；R'为氢或下烷基；R"为氢、下烷基或卤素；Alk为下烷基。这些化合物是通过相应的烷基或苄基醚的脱醚反应制备的。
• Benzyl alcohol derivatives, their preparation and use
  申请人：Sterling Drug Inc.

  公开号：US04496590A1

  公开（公告）日：1985-01-29

  Novel hydroxyphenylaminobenzenealkanols, useful as antiasthmatic agents, are of the formula ##STR1## wherein R is hydrogen, lower-alkyl, lower-alkoxy or halo; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and Y is C.sub.n H.sub.2n wherein n is 1-2. The compounds are prepared by de-etherification of the corresponding phenol alkyl or benzyl ethers; by reduction of the corresponding benzoic acids or esters thereof; or by reduction of ketones wherein --Y--OH is replaced by --COCH.sub.3.

  新型羟基苯胺基苯丙醇，作为抗哮喘剂有用，其化学式为##STR1##其中R为氢、较低烷基、较低烷氧基或卤素；R'为氢或较低烷基；R"为氢、较低烷基或卤素；Y为C.sub.n H.sub.2n，其中n为1-2。这些化合物通过对应苯酚烷基或苄醚的脱醚化制备；通过对应苯甲酸或其酯的还原制备；或通过酮的还原，其中--Y--OH被--COCH.sub.3取代。
• Substituted aminobenzamides and their use as agents which inhibit
  申请人：Sterling Drug Inc.

  公开号：US04510139A1

  公开（公告）日：1985-04-09

  Novel 2-(hydroxyphenylamino)benzamides and oxidation products thereof, useful as inhibitors of lipoxygenase, are of the formulas ##STR1## wherein R is hydrogen, lower-alkyl, halo or lower-alkoxy; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and N.dbd.Z is amino or substituted amino. The compounds of Formula I are prepared by de-etherification of the corresponding alkyl or benzyl ethers; and the compounds of Formula II are prepared by oxidation of the compounds of Formula I where R' is hydrogen and OH is in the 4-position.

  Novel 2-(羟基苯基氨基)苯甲酰胺及其氧化产物，可用作花生四烯酸酶的抑制剂，其化学式为 ##STR1## 其中R为氢、低碳基、卤素或低氧基；R'为氢或低碳基；R"为氢、低碳基或卤素；N.dbd.Z为氨基或取代氨基。式I的化合物通过相应的烷基或苄基醚的脱醚制备；式II的化合物通过在R'为氢且OH位于4位的式I化合物的氧化制备。
• Benzyloxy or alkoxy substituted phenylaminobenzamides
  申请人：Sterling Drug Inc.

  公开号：US04549016A1

  公开（公告）日：1985-10-22

  Novel 2-(hydroxyphenylamino)benzamides and oxidation products thereof, useful as inhibitors of lipoxygenase, are of the formulas ##STR1## wherein R is hydrogen, lower-alkyl, halo or lower-alkoxy; R' is hydrogen or lower-alkyl; R" is hydrogen, lower-alkyl or halo; and N.dbd.Z is amino or substituted amino. The compounds of Formula I are prepared by de-etherification of the corresponding alkyl or benzyl ethers; and the compounds of Formula II are prepared by oxidation of the compounds of Formula I where R' is hydrogen and OH is in the 4-position.

  Novel 2-(羟基苯氨基)苯甲酰胺及其氧化产物，可用作脂氧合酶抑制剂，其化学式为##STR1## 其中，R是氢、低烷基、卤素或低烷氧基；R'是氢或低烷基；R"是氢、低烷基或卤素；N.dbd.Z是氨基或取代氨基。式I的化合物通过相应的烷基或苄基醚的脱醚制备；式II的化合物通过在R'为氢且OH在4位的情况下对式I的化合物进行氧化制备。
• Phenylaminobenzenealkanols and preparation
  申请人：STERLING DRUG INC.

  公开号：EP0122518A1

  公开（公告）日：1984-10-24

  Novel hydroxyphenylaminobenzenealkanols, useful as antiasthmatic agents, are of the formula wherein R is hydrogen, lower-alkyl, lower-alkoxy or halo; R'is hydrogen or lower-alkyl; R"is hydrogen, lower-alkyl or halo; and Y is CnH2n wherein n is 1-2. The compounds are prepared by de-etherification of the corresponding phenol alkyl or benzyl ethers; by reduction of the corresponding benzoic acids or esters thereof; or by reduction of ketones wherein -Y-OH is replaced by -COCH3. The invention also relates to the novel benzyl ether intermediates.

  可用作抗哮喘药的新型羟苯胺苯烷醇的结构式为 其中 R 是氢、低级烷基、低级烷氧基或卤素；R'是氢或低级烷基；R "是氢、低级烷基或卤素；Y 是 CnH2n，其中 n 是 1-2。这些化合物的制备方法有：相应的苯酚烷基醚或苄基醚的脱醚；相应的苯甲酸或其酯的还原；或酮的还原，其中 -Y-OH 被 -COCH3 取代。本发明还涉及新型苄基醚中间体。