18-[[(1S)-1-carboxy-4-[[(1S)-1-carboxypropyl]amino]-4-oxobutyl]amino]-18-oxooctadecanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 18-[[(1S)-1-carboxy-4-[[(1S)-1-carboxypropyl]amino]-4-oxobutyl]amino]-18-oxooctadecanoic acid
• 化学式: C₂₇H₄₈N₂O₈
• 分子量: 528.7
• InChiKey: ORVOHYAGPMJYPZ-VXKWHMMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  37
• 可旋转键数：
  25
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  170
• 氢给体数：
  5
• 氢受体数：
  8

文献信息

• Functionalized Exendin-4 Derivatives
  申请人：Sanofi

  公开号：US20140206609A1

  公开（公告）日：2014-07-24

  The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.
• STABLE, PROTRACTED GLP-1/GLUCAGON RECEPTOR CO-AGONISTS FOR MEDICAL USE
  申请人：Novo Nordisk A/S

  公开号：US20180044394A1

  公开（公告）日：2018-02-15

  The invention relates to novel stable and protracted GLP-1/glucagon receptor co-agonists, to the use of said peptides in therapy, to methods of treatment comprising administration of said peptides to patients, and to the use of said peptides in the manufacture of medicaments.
• US9181305B2
  申请人：——

  公开号：US9181305B2

  公开（公告）日：2015-11-10
• US9365632B2
  申请人：——

  公开号：US9365632B2

  公开（公告）日：2016-06-14