1-Ethyl-4-methylpiperazine-2,5-dione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1-Ethyl-4-methylpiperazine-2,5-dione
• 英文别名: 1-ethyl-4-methylpiperazine-2,5-dione
• 化学式: C₇H₁₂N₂O₂
• 分子量: 156.184
• InChiKey: YDPVAEGCCUQFRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  HCl*Sar-N-EtGly-OEt 在 三乙胺 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以100%的产率得到1-Ethyl-4-methylpiperazine-2,5-dione
  参考文献：
  名称：

  在位置2包含N-烷基氨基酸的肽中的分子内氨解的研究

  摘要：

  许多肽和蛋白质，含Ñ α -烷基氨基酸（包括脯氨酸）在所述第二位置，很容易发生分子内氨解（IA）具有N-末端二肽序列的消除2,5-二酮哌嗪（DKP）。我们合成了一系列短肽，在2位含有N-烷基氨基酸，并研究了它们在乙酸和胺存在下的稳定性。在第二侧链和第三个氨基酸残基，并且烷基化在存在Ñ α第三氨基酸残基的减慢IA。ñ α-第一个氨基酸残基中的烷基残基仅在包含三个或更多个残基的肽中阻碍IA。第一个氨基酸的侧链没有显着影响裂解率。乙酸比氨水对IA的促进作用更强，而叔胺的效果较差。具有蛋氨酸-S-氧化物残基的肽比未氧化的类似物更不稳定，这表明在氨解中S-氧化物基团的分子内辅助。出人意料的是，式Boc–Met-MeXaa-Sar–NHR的中间体化合物在尝试进行酸解脱保护后迅速裂解（内肽水解）。

  DOI：

  10.1016/j.tet.2012.06.056

文献信息

• Photosensitive compositions and applications thereof
  申请人：PROMERUS, LLC

  公开号：US11537045B2

  公开（公告）日：2022-12-27

  The present invention relates to photosensitive compositions containing polynorbornene (PNB) polymers and certain additives that are useful for forming microelectronic and/or optoelectronic devices and assemblies thereof, and more specifically to compositions encompassing PNBs and certain multifunctional crosslinking agents, and two or more phenolic compounds which are resistant to thermo-oxidative chain degradation and exhibit improved mechanical properties.

  本发明涉及含有聚降冰片烯（PNB）聚合物和某些添加剂的光敏组合物，这些组合物可用于形成微电子和/或光电器件及其组件，更具体地说，本发明涉及包含 PNB 和某些多功能交联剂以及两种或两种以上酚类化合物的组合物，这些组合物可抗热氧化链降解，并具有更好的机械性能。
• PHOTOSENSITIVE COMPOSITIONS AND APPLICATIONS THEREOF
  申请人：PROMERUS, LLC

  公开号：US20210116807A1

  公开（公告）日：2021-04-22

  The present invention relates to photosensitive compositions containing polynorbornene (PNB) polymers and certain additives that are useful for forming microelectronic and/or optoelectronic devices and assemblies thereof, and more specifically to compositions encompassing PNBs and certain multifunctional crosslinking agents, and two or more phenolic compounds which are resistant to thermo-oxidative chain degradation and exhibit improved mechanical properties.
• 1-((S)-1-(3-CHLORO-5-FLUORO-2-((4-(1H-PYRAZOL-1-YL)-2-METHYLQUINOLIN-8-YLOXY)METHYL)PHENYL)ETHYL)-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ (BK) B2 RECEPTOR ANTAGONIST FOR TREATING SKIN DISEASES
  申请人：Pharvaris GmbH

  公开号：US20220135542A1

  公开（公告）日：2022-05-05

  The invention relates to a compound according to general formula (I), which acts as a bradykinin (BK) B2 receptor antagonist; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination preparation containing at least one compound of the invention and at least one further active pharmaceutical ingredient; and to said compound(s) for use as in a method of treating a skin disorder; eye disease; ear disease; mouth, throat and respiratory disease; gastrointestinal disease; liver, gallbladder and pancreatic disease; urinary tract and kidney disease; disease of male genitale organs and female genitale organs; disease of the hormone system; metabolic disease; cardiovascular disease; blood disease; lymphatic disease; disorder of the central nervous system; brain disorder; musculoskeletal system disease; allergy disorder; pain; infectious disease; inflammatory disorder; injury; immunology disorder; cancer; hereditary disease; or edema. (I)
• [EN] LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RÉCEPTEUR DE L'ACIDE LYSOPHOSPHATIDIQUE
  申请人：INTERMUNE INC

  公开号：WO2014113485A1

  公开（公告）日：2014-07-24

  Compounds, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds to treat, prevent or diagnose diseases, disorders, or conditions associated with one or more of the Iysophosphatidic acid receptors are provided.
• [EN] PHOTOSENSITIVE COMPOSITIONS AND APPLICATIONS THEREOF<br/>[FR] COMPOSITIONS PHOTOSENSIBLES ET LEURS APPLICATIONS
  申请人：PROMERUS LLC

  公开号：WO2021076131A1

  公开（公告）日：2021-04-22

  The present invention relates to photosensitive compositions containing polynorbornene (PNB) polymers and certain additives that are useful for forming microelectronic and/or optoelectronic devices and assemblies thereof, and more specifically to compositions encompassing PNBs and certain multifunctional crosslinking agents, and two or more phenolic compounds which are resistant to thermo-oxidative chain degradation and exhibit improved mechanical properties.